Lille will hope to claw themselves back into Ligue 1 title contention when they host Paris Saint-Germain at Stade Pierre-Mauroy on Sunday (1945 GMT).
Enrique started his senior career in midfield for his hometown club Sporting Gijon before catching the eye of Real Madrid.
At Real, he would rise to international level, but in 1996 he left the club on a free, joining Barcelona and letting slip that he felt unappreciated in the Spanish capital.
Enrique played in three FIFA World Cups for Spain and won Olympic gold at the 1992 games held in Barcelona.
He was given his start in coaching as the manager of Barcelona B and his first major appointment came in Serie A with Roma in 2011.
After a brief spell as manager of Celta Vigo, he then replaced Gerardo Martino as the manager of Barcelona and would become the club's most successful boss since Pep Guardiola, who departed in 2012.
He left the Basque superclub when his contract expired in 2017 and was named Spain national team coach in July 2018.
Luis Enrique and Barcelona
A native of Gijon, Enrique became a hero in Basque country after he made a controversial switch of clubs in 1996, claiming he was unappreciated at the Santiago Bernabeu.
Enrique struck up a midfield partnership with Luis Figo that drove Barcelona as a soccer force in the late 1990s before the Portuguese star jumped ship to Real Madrid.
Under influential coach Louis van Gaal, Enrique developed even further and showed tremendous consistency and incredible stamina as the Dutchman introduced a possession-based game to the club.
Enrique credits Van Gaal as a massive influence, not only as a player and coach but also as a person.
The latter years of his Barcelona career were a difficult period for the club, who finished sixth in the 2002/03 season before bouncing back to claim a runners-up spot in Enrique's final term. Sadly, his time as club skipper brought little reward as a succession of managers flitted in and out of the Camp Nou.
His good favour with the Barcelonistas from his as a player offered a little insulation from the pressure to succeed. However, delivering the club's fifth Champions League title in his first campaign ensured Enrique wasn't the third manager in a row to be sacked after one season.
Towards the end of the 2016/17 season, Enrique announced he would not be extending his three-year contract with the club, citing a need for rest as his reasoning.
Despite spending just three seasons at the club, Enrique holds a special place among Barcelona managers, with only Guardiola and Johan Cruyff bringing in more silverware to the club in the post-WWII era.
His era as a coach was synonymous with the front three he deployed for much of his time at the club, with Lionel Messi striking up a lethal association with Luis Suarez, who joined the club at the outset of Enrique's time as manager, and Neymar, whose departure came at the end of Lucho's Camp Nou reign.
Enrique timed his exit from Barcelona well, as discontent with the style of play and big-match results grew in his final season, much of it centreing around a 4-0 loss to Paris Saint-Germain. In that final season, the prevailing perception was that despite the presence of world-class talent in every position, the team's performance appeared to be dictated by how well its star man, Lionel Messi, got on.
Messi still counts Enrique alongside Guardiola as the best to have coached him. The club's struggles since Enrique's departure, on the other hand, have painted his time at the club in a different light. While some may insist the 'rot' set in under Enrique, his tenure is a prime example of the challenges of managing a superclub in the 21st century.
All told, Enrique delivered two La Liga, three Copa del Rey, one Supercopa de Espana, a UEFA Champions League, one UEFA Super Cup and a FIFA Club World Cup title in a glittering three-season stay at the Camp Nou.
Enrique is now inextricably linked to Barcelona, which makes it easy to forget that he made his name as a player in the Real Madrid team that struggled manfully against Cruyff's dream team.
While Enrique showed glimpses of star quality at Real Madrid, his best form would be found after crossing the El Clasico divide.
Representing Spain as player and manager
As a player, Enrique had been a Spain stalwart, appearing in three World Cups and the 1996 European Championship. He had also been a member of the Spain Under-23 side that won the country their first gold medal in the men's soccer competition.
He played 62 internationals for Spain, scoring 12 times, but success in major tournaments eluded the country during his playing career.
In his second stint as manager, Enrique showed an early commitment to building for the future, excluding some established players like Isco and firebrand striker Diego Costa.
Spain began the 2022 World Cup by steamrolling Costa Rica 7-1, but then drew with Germany 1-1 before losing to Japan 2-1 in the final group game to sneak into the round of 16 on goal difference.
Reported net worth
Enrique's second deal with Spain is believed to be worth nearly $2million per season, but the coach requested bosses cut his salary by 25% to account for the long inactivity at the start of his tenure.