When: Monday, April 12, 18:00 GMT
How to watch: Sky Sports Main Event
Time is quickly running out for West Brom as they look to save their season and retain their Premier League status.
Sam Allardyce's side shocked the world last weekend with a 5-2 victory over Chelsea. The Baggies will now be looking to prove that their win at Stamford Bridge was no fluke.
One major problem for West Brom is their poor record against Ralph Hasenhuttl's men. Saints have won five straight encounters with the Baggies and they're the bookies favourites to make it six.
Last Three Matches
Southampton 2-0 West Brom (Premier League - October 3, 2020)
Ralph Hasenhuttl's men secured a convincing 2-0 win last time they hosted West Brom at St. Mary's.
Moussa Djenepo opened the scoring just before the half-time break. Oriol Romeu then added a second in the 69th minute as Southampton bagged all three points.
Saints dominated possession, enjoyed more attempts and had more shots on target. The Baggies only outperformed their opponents in two areas; the amount of blocked shots and goalkeeper saves.
West Brom 1-2 Southampton (FA Cup - February 17, 2018)
Southampton got the better of their opponents when the two sides clashed in the Last 16 stage of the 2017/18 FA Cup.
The visitors enjoyed a strong start to the game and went ahead early through Wesley Hoedt.
Dusan Tadic scored Southampton's second in the 56th minute however, West Brom were quick to cut the deficit as Salomon Rondon put the ball in the net just two minutes later.
West Brom 2-3 Southampton (Premier League - February 3, 2018)
A few weeks before their FA Cup clash, Southampton and West Brom were involved in an exciting league clash at the Hawthorns.
Ahmed Hegazy opened the scoring and put the Baggies ahead after just four minutes. Saints searched for an equaliser, but they would need to wait until the 40th minute to find their breakthrough.
Mario Lemina was the man who levelled things up and his goal was quickly followed by a second from Saints defender, Jack Stephens.
James Ward-Prowse then grabbed a third for Southampton after the interval as the visitors built a two-goal cushion.
In spite of Salomon Rondon's late effort for West Brom, the Baggies were unable to complete the comeback and had to settle for a narrow defeat.
Last ten head-to-head games
West Brom wins: 2
West Brom goals: 6
Southampton goals: 13
Eight games to avoid relegation
Southampton, Leicester, Aston Villa, Wolves, Arsenal, Liverpool, West Ham and Leeds United. These eight games are what's left for West Brom.
As things stand, the situation looks rather bleak for Big Sam and his side however, if the Baggies manage to put a string of positive results together, they could give themselves a fighting chance of survival.
A 5-2 thrashing of Chelsea last weekend proved that there's still a lot of fight left in this West Brom side and they won't go down without a fight.
With Southampton, you're never far from goals
If you've been following Southampton in recent weeks, you will know that their games are awash with goals.
Take their last four games for example. A 5-2 defeat to Manchester City was followed by a disappointing 2-1 loss at the hands of Brighton. However, Saints came back strong with a 3-0 win over Bournemouth in the FA Cup and a 3-2 victory over Burnley in the Premier League.
With Saints in goal scoring form and West Brom desperate for a win, we could be in for goals galore.
Danny Ings put on a man-of-the-match performance in his last outing as his goal and assist helped Saints to a 3-2 victory over Burnley.
The striker has scored nine league goals this season and is strongly linked with a move away from St. Mary's.
The player is well priced at 4/1 to score first this Monday night at the Hawthorns.