When: Sunday, May 2, 14:00 GMT
How to watch: Sky Sports Main Event
This has been a truly woeful Premier League campaign for the Gunners.
Mikel Arteta's men are on course to record their lowest league placing since 1994/95 season. To put that in perspective, that's the same year in which DVD's were invented and the PlayStation 1 hit the shelves.
The competition for European places is fierce and Arsenal would need to win all of their remaining games to even have a fighting chance.
With the Gunners unlikely to make the top six, they will have to put all their eggs in one basket and hope that a potential Europa League triumph salvages their campaign.
Newcastle, on the other hand, will be hoping to create more breathing room between them and the relegation places. The Magpies are nine points above the drop zone with five games remaining.
Last Three Matches
Arsenal 3-0 Newcastle (Premier League - January 18, 2021)
The Gunners put on a clinical second-half display to secure a convincing win when they clashed with Newcastle earlier this season.
Two goals from Pierre-Emerick Aubameyang and one from Bukayo Saka sealed all three points.
Arsenal dominated both halves but lacked the final touch in the opening 45 minutes as both teams went into the break goalless.
Arteta's men turned on the style in the second half to make sure of the victory.
Arsenal 2-0 Newcastle (FA Cup - January 9, 2021)
The two clubs also met a few days earlier in the FA Cup. On this occasion though, the contest was a lot closer.
After a goalless first 90 minutes, the match went to extra-time. It was at that point when Emile Smith Rowe and Aubameyang scored the two goals which sent the Gunners through to the following round.
Newcastle competed well but lacked the quality to find a goal at the Emirates.
Arsenal 4-0 Newcastle (Premier League - February 16, 2020)
After another goalless first half, Arsenal were once again forced to turn on the style in the second part of the game.
Aubameyang opened the scoring in the 54th minute while Nicolas Pepe made it two just moments later.
Two more goals in stoppage time from Mesut Ozil and Alexandre Lacazette sealed a convincing win for the Gunners.
Last ten Premier League head-to-heads
Newcastle wins: 1
Arsenal wins: 9
Newcastle goals: 4
Arsenal goals: 18
All eyes on Europa League
Arsenal's long-standing tradition of competing in a European competition every year hangs in the balance.
The Gunners are unlikely to qualify for any UEFA competition through the Premier League, meaning their only hope rests in the Europa League.
Arsenal are gearing up for the return leg of their semi-final with Villarreal. This may force Arteta to make changes and rest key names ahead of that crucial game on Thursday.
Good news for the Magpies then!
Magpies in good form
Newcastle are in good form. It's been a long time since we said that but it's true.
Unbeaten in four, two wins from three, a draw away at Anfield - things are certainly looking up for Steve Bruce's men.
Question is, can they finally overturn their woeful run of form against the Gunners? In ten years, the two clubs have met 19 times yet Newcastle have only record one win during this period.
No Joe Willock. No Lacazette. Who on earth is going to do the scoring in this one?
Nicolas Pepe is certainly one of the contenders. The Arsenal youngster has scored the majority of his goals away from home this season and could be a threat again this Sunday.
He is currently priced at 15/8 to score anytime.