The tournament, which takes place at Harrah's Resort in Atlantic City, will run from October 10 to 15.
Nineball World No.1 Shane Van Boening will start his quest for a sixth US Open title against rising star Joey Tate whilst 2019 Champion Joshua Filler will take on Canada's Jeffrey Kennedy to start his week.
This year's US Open sees the return of some of Asia's top talent with Ko Pin Yi meeting Ben Crawley and brother Ping Chung taking on Robert Blackiston.
The 2013 World Cup of Pool champion Lee Van Corteza will return against Andrew Finnigan. Great Britain's Jayson Shaw will go on the hunt for a second US Open crown against Vincent Beaurivage first up.
This tournament also sees Fedor Gorst, Kristina Tkach, and Margarita Fefilova all make their comebacks in the Nineball Arena and they will meet Coen Bell, Henrik Larsson, and Stephen Folan respectively.
Two-time Mosconi Cup MVP Skyler Woodward will take on Nicholas Yale and five-time US Open champion Earl Strickland will clash with Liu Ri Teng.
The top 128 players in the field were seeded based on the combination of the 2022 Nineball World Ranking and Live Nineball World Ranking.
Full draw for the US Open can be found here.
From Monday, 10 October to Thursday, 13 October fans will be able to enjoy the action globally on the Matchroom Pool Facebook and YouTube pages as well as Matchroom.Live with two tables streamed.
The final two days will be live on Sky Sports in the UK, DAZN in the USA, Canada, Brazil, Spain, and Italy as well as Viaplay in Scandinavia, the Baltics, Poland, and other broadcasters worldwide which can be found here including on Matchroom.Live in countries without a broadcaster.
Photo Credit: Taka G.Wu/Matchroom Multi Sport