The American boxer is currently the unified welterweight world champion, holding the WBC and IBF titles. He is widely considered to be one of the top pound-for-pound fighters in world boxing today.
Before he turned professional, he had a glittering career as an amateur. He is the winner of multiple national titles in the welterweight division. He also won the US Golden Gloves title in 2009, and he followed that up with a silver medal in 2010.
'The Truth' represented the United States at the 2012 Olympics in London and since turning pro later that year he has established himself as one of the top fighters of the modern-era.
Perhaps his defining moment came in unexpected surroundings, at the Bramall Lane Stadium in Sheffield. It was there where he defeated beloved local boy Kell Brook to become the new IBF welterweight world champion.
Spence has a lot that he can go onto achieve before he hangs up his gloves with some huge fights are in the pipeline if they can get made.
Errol Spence Jr's next fight
Spence last fought in December 2020 against Garcia at the AT&T Stadium in Texas. This was contested over the world IBF and WBC welterweight belts.
But "Manny" has been stripped of that belt due to his inactivity. Yordenis Ugas is the new champion after he was elevated from being the holder of the WBA (Regular) belt.
This means that a fight against Ugas is most likely next as Spence tries to add more belts to his resume. The WBA (Super) champion has a record of 26-4, with 12 of his wins coming via stoppage.
The 34-year-old's most recent defeat came at the hands of Shawn Porter in March 2019. This was contested for Porter's WBC welterweight title.
Ugas caused Porter problems but was defeated via split decision after 12-rounds of action. A bout between Spence and Ugas is likely to take place this summer.
The greatest hits: Brook, Garcia and Porter
'The Truth' racked up an undefeated record of 21-0 by August 2016. This earned him the mandatory position for Brook's IBF welterweight title.
The odds were stacked against Spence, as he challenged for the title in front of 27,000 of The Special One's loyalist fans at Bramall Lane, the home of his beloved Sheffield United. This was also the first time that Spence had fought professionally outside of North America.
This did not bother the challenger though, as he gradually broke Brook down the deeper they got into the fight. Power shots kept getting thrown by both men until the American backed the hometown man on the ropes in the tenth-round.
Spence unleashed an onslaught on Brook, which forced the champion to take a knee. He survived the round even though his eye injury was getting worse the closer the fight got to conclusion.
He convincingly defended his title against Lamont Peterson and Carlos Ocampo, picking up stoppage wins in both bouts. Next up was a fight with former world lightweight champion, Garcia.
The step-up in weight was too much for the challenger. Spence dominated as he won every round in the eyes of all three judges to retain his title.
His first fight as a unified champion came against Garcia in December 2020. Even though he was out of the ring for over a year, this did not have much of an impact on Spence. He was comfortably the better fighter and he won via unanimous decision to retain his belts.
Spence is of Jamaican heritage but he was born in Long Island, New York. It was his father who first introduced him to boxing.
The American was in a serious car crash in October 2019 while driving his Ferrari 488 Spider. He lost control of the vehicle, as it veered off the road and flipped.
It was later revealed that Spence had consumed alcohol earlier in that day and he was subsequently convicted on a drink driving charge.
The American was guaranteed to earn £1million for beating the Englishman, with his purses for his latest fights being in the multi-million bracket.