Novak Djokovic will remain world number one after Hubert Hurkacz beat Daniil Medvedev in the Miami quarter-finals.
Medvedev only needed to reach the semi-finals to regain the spot at the top of the rankings that he had a taste of for two weeks in March.
However, defending champion Hurkacz was in no mood to sacrifice his title to Medvedev's quest, and he overcame the Russian 7-6, 6-3.
The result means that Medvedev will go into the clay season, his least favourite in the tennis calendar, just behind Djokovic, who has played just three matches so far this year.
"For me was more important in a way just to win the match itself than to become a number one by winning the match," said Medvedev.
"I saw it more as a bonus. So I don't feel like I was tight or anything because of this.
"To be honest, I played a lot of matches where I had the pressure, different [types], and it's not like something new happened today in terms of like going out of court and feeling crazy tight or something. So I don't think that nerves were part of this."
Medvedev also said that injury and illness also played a major role in the defeat.
"All the match I was not feeling my best. But, you know, sometimes it happens," he explained.
"I don't know the actual reason. Maybe the heat. But I was feeling super, like, dizzy, tired, and there was this long game where I couldn't serve anymore.
"Then in the locker room I was cramping quite much, so physically was not easy. But at the same time, that's part of the game."
Despite the defeat and disappointment of missing out on world number one, Medvedev remained in philosophical mood in his performance in general.
"I'm kind of happy about the tournament in Miami in a way of tennis," he said. "I managed in Miami to find just a little spark to try to make it work. Today was not enough, but I'm happy that I saw that I'm able to do it.
"I'm [going] in the right direction, so it's good."