When: Sunday, August 15, 4.30pm BST
Where: Tottenham Hotspur Stadium
How to watch: Sky Sports
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The biggest Premier League transfer story is yet to unfold as questions remain over the future of Harry Kane.
The player recently returned from holiday and hasn't had a lot of time with the rest of the Tottenham squad.
This certainly doesn't bode well for his chances of starting against Manchester City. Manager Nuno Espirito Santo reiterated in his press conference that "all the squad that work on a daily basis" would be in contention.
Then again, Nuno could be keeping his cards close to his chest as he looks to make a statement early on in the campaign.
The Cityzens won't be pulling any shots on this occasion though as they look to kick off the defence of their title in style.
Last three matches
Manchester City 1-0 Tottenham (Carabao Cup - April 25, 2021)
The previous head-to-head meeting between these clubs came in the final of last season's Carabao Cup.
Jose Mourinho was given his marching orders before the game, meaning Spurs were led by managerial newbie Ryan Mason.
The match was heavily dominated by the Cityzens who prevailed 1-0 courtesy of Aymeric Laporte's 82nd minute winner.
Manchester City 3-0 Tottenham (Premier League - February 13, 2021)
In their last meeting at the Etihad, it was Manchester City who romped to a comfortable 3-0 win.
A well-converted penalty from Rodri was followed by a second-half Ilkay Gundogan brace.
This was a disappointing afternoon for Spurs as their five-year winless run away at Man City continued.
Tottenham 2-0 Manchester City (Premier League - November 21, 2020)
It's incredible how fast things change in soccer. This game was less than a year ago and back then, Spurs were considered to be actual title contenders following their win over the Cityzens.
Mourinho's men opened the scoring with Heung-Min Son getting on the scoresheet in the fifth minute.
Laporte had a goal disallowed on the half-hour mark but that was as close as City came to scoring.
Tottenham added a second in the 65th minute through Giovani Lo Celso as the three points stayed in London.
Last ten head-to-heads
Tottenham wins: 3
Manchester City wins: 6
Tottenham goals: 11
Manchester City goals: 15
What is the current state of Spurs?
Away from the Harry Kane drama, it is indisputable that Tottenham still have a wealth of talent on their books. Question is, do they have enough to challenge for anything serious this season?
There's been an overhaul of players over the summer with the likes of Gareth Bale returning to Spain, Toby Alderweireld moving to Qatar, Erik Lamela joining Sevilla and even young Juan Foyth transferring to Villarreal.
There have also been some incomings. Nuno Santo welcomed Bryan Gil for £22million while Cristian Romero and Pierluigi Gollini have both come on loan from Atalanta.
Spurs are still a couple of signings short from really challenging the cream of the crop but there's nothing to suggest why they couldn't pull off some big results this season.
Santo has proven himself to be a capable operator at Wolves and this is an opportunity for him to make some serious noise in the Premier League.
City's winless run at Spurs
Manchester City may have won their last two games against Tottenham but their run away from home is far less impressive.
City have lost their last three visits to the Tottenham Hotspur Stadium, conceding five goals and scoring none in the process.
Pep Guardiola has never won at this venue and he will be desperate to change that this Sunday.
The Spaniard has been shaping his squad over the summer with his biggest signing coming at great expense. Jack Grealish, who cost the club £100million, will have a weight of expectations on his shoulders as he looks to pay off the transfer fee.
Despite the investment, it still seems like City are missing some fire-power up front. Gabriel Jesus is a great talent but his nine goals in 29 Premier League appearances last season was hugely disappointing.
Ferran Torres, who played up front in the Community Shield defeat to Leicester, is also facing his critics after bagging a measly seven goals last term.
One man who loves to score against Man City is Son.
The South Korean has scored in all three of his most recent home games against the Cityzens.
At the price of 3/1, Son offers great value in being Tottenham's first goalscorer in this game.
From a Man City perspective, the man to back is Raheem Sterling.
After a stellar Euros tournament, surely the England international is about to get more game time.
If that's the case, the 17/10 offer on Sterling to score anytime is the way to go.