When: Tuesday, 11 May, 20:15 GMT
How to watch: BT Sport
Can Southampton catch Palace?
They certainly have a chance, but their performances need to improve - starting on Tuesday. Saints are four points behind their next opponents and victory would move them just a sole point off Palace, who currently occupy 13th in the league table.
Southampton have not won in their last five matches and fans had little to get excited about at the weekend when losing 2-0 against Liverpool. With very little to play for apart from league position, it is perhaps understandable as to why Ralph Hasenhuttl's side have taken their foot off the accelerator.
Crystal Palace are in a similar position; they have secured Premier League safety and did so a while ago. This is also reflected in their results recently, although their performances have been more encouraging than Southampton's.
In their last five games, the Eagles have lost against Chelsea, Leicester and Man City, who all have more to play for than Roy Hodgson's men. Palace's other results have been a creditable draw with Everton and a good away win against already-relegated Sheffield United.
Last three Premier League meetings:
Crystal Palace 1-0 Southampton (September 12, 2020)
This was a low-key affair where a single goal was enough for Palace to bag the victory. Star man Wilfried Zaha netted his 50th league goal in the 13th minute.
Palace swept forward on the counter attack and Andros Townsend's back post cross was stylishly volleyed in by the Ivory Coast international.
Southampton had chances in the shape of Nathan Redmond, Che Adams and Danny Ings who was denied a last-gasp equaliser by Vicente Guaita.
Crystal Palace 0-2 Southampton (January 21, 2020)
Saints secured their fourth away win in succession with this 2-0 victory at Selhurst Park. The three points moved them into the top half of the table.
Stunning goals from both Nathan Redmond and Stuart Armstrong saw them turn in an impressive display. Manager Ralph Hasenhuttl described it as 'perhaps our best away performance (of the season)'.
Southampton 1-1 Crystal Palace (December 28, 2019)
An entertaining draw took place at St Mary's as Southampton moved four points clear of the relegation zone and Hodgson's Palace stayed ninth.
After a goalless first half, James Tomkins - making his 350th career appearance - headed in a cross via the underside of the crossbar.
Later, Danny Ings made the most of a Martin Kelly mistake to grab his 12th league goal of the season as Southampton came away with a draw.
Premier League head-to-head:
Southampton wins: 13
Crystal Palace wins: 4
Southampton scored: 34
Crystal Palace scored: 19
Are Southampton missing Danny Ings?
Southampton's top scorer has only played 25 matches this season and has not played in the league since a 2-1 loss to Spurs, three games ago. Without the striker, his side have not won a match.
Ings, who has 10 league goals to his name, could return on Tuesday to boost Southampton ranks. His manager Ralph Hasenhuttl said in his press conference, "I don't know it yet, it's possible. We'll have a look today in the session and then we can decide."
Just as crucial to Crystal Palace are Wilfried Zaha and Eberechi Eze. Zaha has 10 goals and two assists in 26 Premier League outings this season and Eze has four goals and five assists in 32 league appearances.
Eze, in particular, was on song against Sheffield United. The two tricky players will be looking to provide Christian Benteke with ammunition and the Belgian is in decent form following his goal at the weekend.
Scoreline prediction: Southampton 2-3 Crystal Palace
A high scoring game could be on the cards as neither team has anything to lose and both outfits currently lack confidence.
If Danny Ings does return for the home team, he will be a threat in attack and James Ward-Prowse will be looking to get back to form after not being at his best recently.
Palace experimented with a more attacking line-up against Sheffield United and Roy Hodgson liked what he saw with his team creating plenty of chances. If Hodgson opts for the same tactics, they are likely to be strong going forward but liable to a fast Southampton team in their defence - which means lots of goals are a distinct possibility.
Wilfried Zaha has once again impressed this season and is considered the away teams biggest threat going forward.
Michael Obafemi has come off the bench in past games for Southampton, but he could get more game time after impressing in his brief appearances.
The striker represents value at 15/2 to be the last goalscorer with Unibet.