However, the Saints are no pushovers and are capable of plunging the Gunners further into crisis.
The Blues have conceded three goals in each of their last two matches, while the return of Patrick Bamford looks set to reinvigorate the Leeds attack.
Likely to get a warm reception, he will put nostalgia to one side as he looks to maintain Villa's resurgence.
With goals likely to flow in all three fixtures, Planet Sport Bet have produced an exciting bet boost, with all six sides to score now 6/1 from 5s.
Arsenal vs Southampton
Just as things were beginning to look up for Arsenal, the Gunners are once again in a downward spiral following a run of three defeats in four games.
Mikel Arteta's men saw their 10-match unbeaten run shattered by Liverpool three weeks ago. Their embarrassing 4-0 loss at Anfield was followed a 2-0 victory over Newcastle and two further defeats against Man United and Everton.
Despite their slump, the Gunners are still finding the back of the net on a consistent basis. Arteta's men have bagged eight times in their last six outings.
Their forthcoming opponents, Southampton, are also enjoying a fruitful run in front of goal.
Ralph Hasenhuttl's side have scored at least one goal in nine of their last 10 competitive games.
Interestingly, the BTTS bet has enjoyed a lot of success in this fixture. Six of the last eight Premier League head to heads have seen both of these sides find the back of the net.
Considering both Arsenal and Southampton could do with a win, there's a strong chance we'll see another high-octane encounter.
Chelsea vs Leeds
Two games without a win may not sound like much but considering the standards Thomas Tuchel sets at Chelsea, the German must be pulling his remaining hair out.
His Blues side were knocked off the top of the Premier League after letting slip a 2-1 lead at West Ham to lose 3-2.
Chelsea followed up that league disappointment with another frustrating outing in Europe. Tuchel's men were 3-2 up against Zenit St Petersburg going into stoppage time yet they still failed to secure a victory.
The Blues will be looking to vent their frustrations on a Leeds United side far from their peak.
Marcelo Bielsa's side have only lost three of their last 10 Premier League outings but then again, they've also won three during that same period.
Consistency remains elusive at Elland Road but that doesn't mean the Whites can't cause problems.
Bielsa's attacking style has been rewarded with seven goals from Leeds' last six games.
This might not sound an enormous tally but with Patrick Bamford notching from the bench last weekend, Leeds are now a far more attractive proposition in the both teams to score market.
Liverpool vs Aston Villa
Liverpool may be the Premier League's top goalscorers - with 44 to their name - but the Reds are also prone to conceding one or two along the way.
Another team in claret and blue who will be looking to cause them problems are Aston Villa.
Steven Gerrard's return to Anfield will make for a great story but despite his links with the Reds, the new Villa boss will be concentrating all his efforts on derailing his former side's title push.
Since Gerrard's arrival, the Villans have enjoyed an impressive turnaround. A run of three wins from four games has lifted the side into the top half of the table - just six points behind fifth-placed Tottenham.
Villa are also in good goalscoring form having found the back of the net seven times in their last four matches.
While Liverpool are favourites, keeping a clean sheet is by no means a given. They haven't managed to do so in their three previous head to heads.