Borussia Dortmund vs Eintracht Frankfurt - Saturday 14:30 GMT
The weekend kicks off with a huge Bundesliga top four battle between Borussia Dortmund and Eintracht Frankfurt.
This fixture will also set the stage for an intriguing battle between two of the league's best young strikers.
Both Erling Haaland and Andre Silva have scored 21 goals this season and the two men are without doubt the ones to watch in this encounter.
Real Madrid vs Eibar - Saturday 15:15 GMT
Zinedine Zidane's men are unbeaten in ten games across all competitions; eight of which have been victories for Los Blancos.
Eibar are currently in the relegation zone and have amassed just four league wins this season. If Real are serious title challengers, they should dispatch Eibar with goals to spare.
PSG vs Lille - Saturday 16:00 GMT
France is preparing for one of the biggest Ligue 1 fixtures in years as PSG host Lille in what many describe as a title deciding contest.
The Parisians are currently top of the table but only lead Lille by virtue of goal difference.
Les Douges lost their place at the top of Ligue 1 following a shock defeat to Nimes before the international break. However, the title will still be in their hands if they can somehow pull off a victory at the Parc des Princes.
A draw doesn't help anyone but we may be heading in that direction.
Betting: Draw at 27/10 (PaddyPower)
Torino vs Juventus - Saturday 17:00 GMT
It's derby time in the north of Italy as Torino and Juventus clash in the infamous Derby della Mole.
The international break couldn't have come at a better time for Juventus. Cristiano Ronaldo and co had two weeks to reflect on their shock defeat to Benevento which may just have cost Juve the defence of their title.
Andrea Pirlo's side can start afresh this weekend however, in spite of Torino's lowly league position, this is by no means an easy fixture.
Torino are battling for their Serie A survival and recent wins over Sassuolo and Cagliari proved that there's still plenty of fight left in them.
Leicester City vs Man City - Saturday 17:30 GMT
You want excitement? You'll get plenty of it here!
Pep Guardiola's men are cruising towards the title however, they don't have an exceptionally great record against the Foxes.
One man who has been a constant pain for the Cityzens is one Jamie Vardy. The former England international has bagged nine goals - including two hat-tricks - in games against the Sky Blues. If City aren't careful, he could haunt them again this weekend.
RB Leipzig vs Bayern Munich - Saturday 17:30 GMT
Bayern Munich have completely dominated the Bundesliga over the past decade however, could their reign of destruction be nearing an end?
We'll get an answer to that question this weekend as second-placed RB Leipzig host the league leaders in what could be the game of the season in Germany.
Julien Nagelsmann's side are just four points away from the Bavarians and they could close the gap to just one with a win at the Red Bull Arena.
With all other clubs too far behind, Leipzig pose the only real threat to Bayern's pursuit of their ninth consecutive title.
Plus, did we mention Robert Lewandowski is not available?
Betting: RB Leipzig to win at 19/10 (SkyBet)
Bologna vs Inter Milan - Saturday 19:45 GMT
Inter will be looking to create further headway in the Serie A title race when they travel away to Bologna.
Antonio Conte's men are top of the table and are six points clear of AC Milan with only two months of the season remaining.
Bologna, however, are in good form and they will prove tough challengers - especially on home turf.
This will be a close one but Inter are expected to get the job done.
Arsenal vs Liverpool - Saturday 20:00 GMT
Both clubs have so far endured rather forgettable campaigns. However, with Liverpool still chasing a top four finish and Arsenal looking to make a push for Europe, there is a lot riding on this fixture.
Liverpool haven't won away at the Emirates stadium since 2016 but recent results show that the Reds are far better on the road then they are at Anfield.
Arsenal, meanwhile, have struggled to find consistency all year long and they could be punished by the Reds if they fail to turn up.
Betting: Over 3.5 goals at 2/1 (bet365)
Man United vs Brighton - Sunday 19:30 GMT
Man United faced an FA Cup exit at the hands of Leicester just before the international break.
Brighton are more than capable of replicating Leicester's performance this weekend and a shock win for the Seagulls should certainly be on the cards.
United are comfortably sitting in the top four and may not have the intensity of Graham Potter's men who are still battling to retain their place in the Premier League.
Betting: Brighton to win at 17/4 (SkyBet)