Having won nine of their last 10 games, it's fair to say that the Blues are firing on all cylinders. However, if they are to maintain a stronghold at the top of the Premier League table, they will need to end their dreadful run against the Red Devils.
Speaking of United, the managerial situation at the club is complicated but we know that Michael Carrick will be in charge for the trip to London. The former United player led the team to a Champions League victory in midweek and he'll be looking for more this weekend.
When, where and how to watch
When: Sunday, November 28, 16.30 GMT
Where: Stamford Bridge
How to watch: Sky Sports
Best bets for Chelsea vs Man United
Say what you want about Ole Gunnar Solskjaer but the man certainly knew how to get a result against Chelsea. It makes you wonder why some Blues fans were calling for him to stay.
In eight head-to-heads during the Ole era, United won this fixture four times and only suffered one defeat. Interestingly, three of those victories came away at Stamford Bridge.
In order to find Chelsea's last home win over the Red Devils you would need to go all the way back to 2017.
Back then, the two clubs were managed by Antonio Conte and Jose Mourinho while the starting line-ups included such names as Cesc Fabregas, Eden Hazard, Henrikh Mkhitaryan and even Antonio Valencia - who was the captain.
Since then, the personnel may have changed but the narrative has remained the same. Chelsea are still top title contenders while Manchester United continue to wander aimlessly.
Considering the trajectory that both these clubs are on, it's no surprise to see Thomas Tuchel's side as heavy favourites in the betting. But that is also precisely the reason why our opening selection is to back Manchester United.
It's not often that the Red Devils are available at 5/1. Despite all their troubles, that is a price that simply can't be left untouched.
After all, United have a good record away at Chelsea and following their win over Villarreal, there's no reason why they couldn't kick on and cause the Blues some problems. They're certainly worth a punt at the current price.
Last three meetings
Chelsea 0-0 Man United (Premier League - February 28, 2021)
Despite missing Edinson Cavani and Paul Pogba, Man United managed to grind out a draw on their last visit to Stamford Bridge.
Chelsea enjoyed more possession, more shots and more attacks but ultimately, they couldn't find a way past the visitors.
Man United 0-0 Chelsea (Premier League - October 24, 2020)
Their earlier meeting that season also failed to entertain.
It was the Red Devils who showed more attacking incentive but in the end, there was nothing to shout about at Old Trafford.
Man United 1-3 Chelsea (FA Cup semi-final - July 19, 2020)
Frank Lampard led Chelsea to the FA Cup final as his side powered past Man United at Wembley stadium.
Olivier Giroud and Mason Mount gave the Blues a two-goal lead before Harry Maguire's own goal all but secured the result.
Bruno Fernandes converted a late penalty but it was Chelsea who comfortably prevailed at the home of soccer.
Last 10 head-to-heads
Chelsea wins: 2
Man United wins: 4
Chelsea goals: 8
Man United goals: 14
Not a lot of goals in the past
It's been a long time since we last saw a goal in this fixture. The last two encounters failed to provide much drama as both ended goalless.
We're not expecting a hat-trick of scoreless ties but this weekend's encounter does provide an enticing price in the under 2.5 goal market.
This is a bet which has landed in three of the last four games between Chelsea and Manchester United. What's more, at the price of 6/5, it's likely to draw a lot of interest.
Goalscorer bets for Chelsea vs Man United
If Man Untied are to win, they will need their marquee man to deliver once again.
Cristiano Ronaldo was on the scoresheet during United's 2-0 win over Villarreal in midweek. The Portugal international has now scored 10 goals in 14 appearances for the Red Devils this season - more than Mason Greenwood, Bruno Fernandes and Edinson Cavani combined.
The 36-year-old is currently available at 2/1 to score anytime and is sure to attract a lot of takers.
Another man to watch is Marcus Rashford. The England international recently returned from injury and is yet to register a full game under his belt.
Nevertheless, the 25-year-old has five career goals against Chelsea and could haunt them again as Greenwood and Cavani miss out through injury.
From Chelsea's perspective, it's Romelu Lukaku who leads the anytime goalscorer market.
The former Red Devil will be keen to net against his former team but considering he hasn't played in over a month, perhaps this is not the ideal time to back the big Belgian.
Instead, Timo Werner offers good value at around the 13/8 mark.
The German is yet to flourish at Stamford Bridge but he at least marked his return from injury with a goal against Juventus in midweek.