Tough start for the reigning champions, exciting opponents for the newly promoted clubs, and one of the biggest rivalries in the country. What more could you ask for?
Here's the pick of the action on the opening weekend of the new Premier League season.
Brentford vs Arsenal
This is a fixture that will certainly excite Brentford fans. Apart from hosting one of Premier League's biggest clubs, the Bees will also have the chance to prove they can hang with the big boys.
After getting Brentford promoted to the top-flight, it will now be interesting to see whether Thomas Frank can keep the club in the Premier League.
With the 47-year-old insistent on an attractive style of football, many people will also be fascinated to see what his approach will be.
As for Arsenal, this will be a tricky opening test. But then again, it could have been worse.
Mikel Arteta needs a strong start to the season after an underwhelming 2020/2021 campaign. If the Spaniard gets his team off to a losing start, then the pressure could seriously mount on the 39-year-old.
One man to keep an eye on is Brentford's Ivan Toney. After netting a record 31 goals in the Championship last season, the forward will now be looking to test himself at the highest level.
Another exciting element to this game is the potential atmosphere at the newly built Brentford Community Stadium. The Bees are yet to play in front of packed stands due to COVID-19. If the ground is allowed to be filled, then it could make for an atmosphere to remember.
Manchester United vs Leeds United
This is always a fixture to get excited about.
This is undoubtedly a difficult opening game for the Whites. But if we learnt anything last season, it's that Leeds are not phased by the big occasions.
With the Red Devils currently being strongly linked with Borussia Dortmund winger Jadon Sancho, the thought of him making his debut against one of United's biggest rivals is very exciting. It would certainly make for fascinating viewing.
After a stellar first season back in the Premier League, Leeds will be hoping to have another impressive campaign. Starting with a win at Old Trafford would most certainly mark the perfect start.
Norwich City vs Liverpool
Just like in 2019, Norwich City will mark their return to the Premier League with a clash against Jurgen Klopp's Liverpool.
This may be a tough start for Daniel Farke's team, but it is a chance to test themselves against one of the best teams in the division.
Norwich begin life in the top tier without Emiliano Buendia. The Argentinian winger was in exceptional form last season and played a big role in their successful race for promotion. Taking on Liverpool without him will be a real test to see how they cope.
Since Jurgen Klopp arrived on Merseyside, the Reds have won four of their five opening Premier League games. They have also never failed to score less than three goals on opening weekends since his appointment. If they are to keep up this record, it could be a long 90 minutes for Norwich.
Following City's convincing relegation from the top-flight a couple of seasons ago, the club will be desperate to prove that they belong in the Premier League. If they were to overcome giants Liverpool in their opening match, that would certainly underline that message.
Tottenham Hotspur vs Manchester City
However, this is also not the easiest of starts for Pep Guardiola's Manchester City who have lost on all three of their previous visits to the Tottenham Hotspur Stadium.
Whoever becomes the new Spurs manager will be faced with the difficult task of beating the Premier League's dominant force in their very first match in charge. While this fixture is not ideal, it does present the new man in charge with a chance to get off to a perfect start.
The Harry Kane transfer saga is bound to be the most interesting story of the summer. With City being one of the clubs strongly linked with the England striker, it makes you wonder whether he could be a Man City player by the time this fixture comes around. That would certainly make things a lot more interesting.