When: Saturday, July 16, 02:30am BST
How to watch: Premier Sports
Despite missing many of their key players, the US are expected to walk all over their opponents in Kansas City.
Greg Berhalter's men kicked off their CONCACAF Gold Cup campaign with a slender 1-0 win over Haiti last Sunday. Sam Vines scored the solitary goal as the United States bagged all three points.
This time round, the expectations are much higher as the US take on a side mainly made up of players who compete in Martinique's domestic competition.
The small Caribbean Island has a population of just 370,000 - around 10 times smaller than the US.
What's more, Martinique were rather clinically dealt with by the Canadians in their opener - losing 4-1 despite taking an early lead.
Last two matches
United States 3-2 Martinique (Gold Cup - July 13, 2017)
The previous meeting between the two nations took place during the 2017 edition of the Gold Cup.
Following a goalless first-half, the group stage encounter eventually sprang into life.
Omar Gonzalez and Jordan Morris gave the hosts a 2-0 lead but Martinique were far from beaten.
Instead, a ten-minute brace from Kevin Parsemain sensationally levelled the score.
A 76th minute winner from Morris helped the United States avoid what would have been international sporting embarrassment.
Martinique 0-2 United States (Gold Cup - July 13, 2003)
One other meeting of significance took place 18 years ago, also in the Gold Cup.
This was America's opening game in the 2003 edition of the tournament.
In the end, two goals were enough for the Untied States to seal the win and the three points.
Last two head-to-heads
Martinique wins: 0
US wins: 2
Martinique goals: 2
US goals: 5
Where are America's stars?
Why is that?
Well, with European clubs returning to training ahead of the new season, the US manager believed that these players could do with a bit of a break considering they all heavily featured in the country's successful Nations League campaign.
But then again, their absence could be just what Gregg Berhalter needed. The manager is building his squad for the 2022 World Cup and many of the fringe players have not been given many opportunities to shine.
Martinique facing long odds
Martinique beating the United States would be up there with some of the biggest shocks in international soccer.
The US might be fielding a second-rate team but they should have enough fire-power to overcome a national side that mostly consists of players from the Martinique Division d'Honneur - no disrespect.
The small Caribbean Island enjoyed its biggest success in the Gold Cup 19 years ago when they reached the quarter-final.
Chances of that happening in this tournament depend on the outcome of this game. The odds are certainly not looking good.