When: Sunday, April 25, 14:00
How to watch: Sky Sports Main Event
On that occasion, Ole Gunnar Solskjaer's counter-attacking style of football prevailed over El Loco's infamous Bielsa press.
Man United's 6-2 victory has placed high expectations on this upcoming rematch as fans await another blockbuster.
Sunday's contest is finely poised and it is a fixture with countless talking points. From the historic rivalry between both teams to the contrast in football philosophies, this is without a doubt the must-see event of the weekend.
Last Three Matches
Man United 6-2 Leeds United (Premier League - December 20, 2020)
Solskjaer got the better of his Leeds counterpart when Manchester United thrashed the West Yorkshire side in their earlier Premier League encounter.
Leeds opted for their usual high press however, that strategy quickly backfired as Scott McTominay scored a brace in the opening three minutes.
Things quickly deteriorated as Bruno Fernandes and Victor Lindelof put United 4-0 up inside 40 minutes.
Liam Cooper got Leeds on the scoresheet before the break but two more United goals on the other side of the interval all but settled the result.
Stuart Dallas scored a second for Leeds who dominated possession but were ultimately outdone by Man United's clinical display.
Leeds United 0-3 Man United (EFL Cup - September 20, 2011)
Man United's last visit to Elland Road saw them come away with a comprehensive victory in the EFL Cup.
Michael Owen's 30-minute brace was followed by a Ryan Giggs goal as United took a 3-0 lead before half-time.
United took their foot off the gas in the second half but held on to a clean sheet and progressed in the competition.
Man United 0-1 Leeds United (FA Cup - January 3, 2010)
One of Leeds United's biggest wins of the decade came in the early days of 2010 when the Championship outfit knocked out Manchester United in the FA Cup.
Jermaine Beckford scored the only goal of the game in the 19th minute as Simon Grayson's side pulled off an incredible victory.
In spite of all their quality on the pitch, Man United were unable to turn things around in the second-half.
Last ten head-to-head games
Leeds United wins: 2
Man United wins: 6
Leeds United goals: 12
Man United goals: 21
Man United's unbeaten streak away from home
As things stand, Manchester United are the last remaining team in the Premier League which hasn't lost an away league game this season.
A lot of United's success can be attributed to their away form which consists of 10 wins from 16 games.
The Red Devils are 11 points behind Man City and a late title charge seems unlikely. However, Solskjaer's men will want to maintain their pressure on the Cityzens in case of any slip ups from Pep Guardiola's men.
Leeds can go above Arsenal
Leeds United have produced one of the finest campaigns for a newly promoted side in Premier League history.
It can be argued that there have been other clubs who finished higher in the table however, considering the level of competition this season, they've done incredibly well to stick around that 10th spot.
But above all, Leeds are arguably one of the best teams to watch in the Premier League this season. Fans are often on the edge of their seats watching the Whites; something that cannot be said about Man United's conservative style of football.
Should the Whites win, or even hold the Red Devils to a draw, they will leapfrog Arsenal into ninth spot in the table.
There is a long list of Manchester United names on the goalscorer betting list however, our recommendation is to back Leeds' Patrick Bamford.
The Whites frontman is priced at 6/4 to score anytime which is a decent price considering he is the Premier League's fifth best goal scorer.