When: Wednesday, March 3, 20:15 GMT
How to watch: Sky Sports
Last three Premier League meetings:
Manchester United 1:3 Crystal Palace (September 19, 2020)
Goals from Andros Townsend and Wilfried Zaha earned Roy Hodgson's team their second straight victory at Old Trafford.
United dominated possession throughout the 90 minutes, but the visitors were far more clinical and converted their opportunities into goals.
Crystal Palace 0:2 Manchester United (July 16, 2020)
The stakes were high and United had to win their game with Crystal Palace in order to strengthen their position.
Thankfully for Solskjaer's men, goals from Marcus Rashford and Anthony Martial helped the Red Devils to a 2-0 win away at Selhurst Park. United and Chelsea ended up taking the two Champions League places while Leicester missed out.
Manchester United 1:2 Crystal Palace (August 24, 2019)
A last second Patrick van Aanholt winner sealed a famous victory for Crystal Palace - their first at Old Trafford since 1989.
Palace started the game brightly and opened the scoring on the half-hour mark through Jordan Ayew. United fought back and managed to grab the equaliser in 89th minute courtesy of Daniel James' headed goal.
It seemed like United could go on and win the game in stoppage time however, in a spectacular turn of events, it was the visitors who took the spoils.
Head-to-head since 1989
Crystal Palace wins: 5
Manchester United wins: 22
Crystal Palace goals: 23
Manchester United goals: 58
United's away form too strong
Man United are in the midst of a ten-game unbeaten run when it comes to games away from home in all competitions. In fact, Ole Gunnar Solskjaer's men are the only Premier League side to have avoided an away league defeat all season long.
The only two losses that United have suffered on the road, both came in the Champions League. A 2-1 loss to Istanbul Basaksehir and a 3-2 defeat to RB Leipzig condemned United to Thursday nights as they were dumped out of the competition and sent packing to the Europa League.
United have drawn their last three away Premier League games and two of those came against Chelsea and Arsenal. If those two clubs failed to end United's run, then the chances of Palace managing this look slim.
United's last five away Premier League games:
Chelsea 0-0 Man United
Real Sociedad 0-4 Man United (Fernandes (2), Rashford, James)
West Brom 1-1 Man United (Fernandes)
Arsenal 0-0 Man United
Fulham 1-2 Man United (Cavani, Pogba)
Can Palace threaten?
United are the clear favourites with the bookies but that doesn't mean they can expect an easy ride at Selhurst Park.
One common factor about those victories was the influence of Wilfried Zaha. The former United man is unlikely to feature this Wednesday night and that could leave Hodgson's side without enough fire power to really go after the visitors.
The absence of Zaha and a clear lack of momentum leaves Palace in a difficult position. The team has only managed three wins from their last ten games in all competitions and they don't look like they could pull off another famous win over the Red Devils.
United, on the other hand, love to play away from home and they're unbeaten at Selhurst Park since 1991.
This will be a close game but at the end of the day, United look set to prevail and take the three points back to Manchester.
Man United to win 2-1 is well priced at 13/2.
Fernandes is priced at 5/4 to score anytime and 7/2 to score first. Marcus Rashford also offers good odds at 7/5 to score anytime and 4/1 to score first.
Man United to win 2-1 at 13/2
Bruno Fernandes to score anytime at 5/4
Man United to win and both teams to score at 23/10
Man United to win by one goal at 23/10