The Portugal star said that head coach Erik ten Hag and others want him out of Old Trafford, in excerpts of a 90-minute interview with Piers Morgan Uncensored, which will be broadcast next week on TalkTV.
When asked if United's hierarchy were trying to force him out of the club, Ronaldo said: "Yes, not only the coach, but another two or three guys around the club. I felt betrayed."
When quizzed again if senior club executives were trying to oust him, the 37-year-old said: "I don't care. People should listen to the truth.
"Yes, I felt betrayed and I felt like some people don't want me here, not only this year, but last year too."
The Planet Sport news agency has contacted United for comment.
Ronaldo said he did not respect boss Ten Hag, admitting: "I don't have respect for him because he doesn't show respect for me. If you don't have respect for me, I'm never gonna have respect for you."
Ronaldo refused to come on as a substitute in last month's win over Tottenham, leading to him being banished from the squad for the subsequent trip to Chelsea, although he then returned to the fold.
Ronaldo, who was heavily linked with a move away from Old Trafford in the summer, also hit out at former United team-mate Wayne Rooney over criticism the former had received for refusing to come on against Spurs.
Writing in The Sun newspaper, Morgan revealed Ronaldo said: "I don't know why he criticises me so badly…probably because he finished his career and I'm still playing at a high level.
"I'm not going to say that I'm looking better than him. Which is true…"
Ronaldo also claimed United had not progressed as a club since the departure of Sir Alex Ferguson in 2013.
Ronaldo, who played under Ferguson for six years during his first spell at United before joining Real Madrid in 2009, said: "I don't know what is going on, but since Sir Alex Ferguson left I saw no evolution in the club, the progress was zero.
"For example, we have an interesting point that how the club as Manchester United, after (they) sack Ole (Gunnar Solskjaer), they buy - they bring (in), sports director Ralf Rangnick, which is something that nobody understands.
"This guy is not even a coach. A bigger club like Manchester United brings (a) sports director - surprised not only me but all the world, you know.
"Nothing changed. Surprisingly. Not only the pool, the jacuzzi, even the gym…Even some points, the technology, the kitchen, the chefs, which is, I appreciate, lovely persons.
"They stopped in a time, which surprised me a lot. I thought I will see different things…different, as I mentioned before, technology, infrastructure.
"But unfortunately, we see many things that I used to see when I was 20, 21, 23. So, it surprised me a lot."