Wade is targetting his first PFL championship after securing his place in a record fourth career semi-final.
The 34-year-old came within touching distance of the $1million winner's prize last year, but faced an agonising final defeat against Movlid Khaybulaev in Hollywood, Florida.
Should Wade get the better of Loughnane in London on August 20, he will earn another shot at glory against either Ryoji Kudo or Bubba Jenkins.
Despite being one of the biggest names in the Professional Fighters League, Wade recently hit out at his play-off pay, which is understood to be substantially lower than his regular season purse.
Nevertheless, he has since held talks with the organisation and raised his concerns, saying: "We spoke. I spoke to my managers, so as far as that goes, I just want to move on beyond that.
"I think that we said what we needed to say. We had a conversation, it was good, so I just want to focus on the fight."
Wade is locked into a fixed purse for the Loughnane bout, but being in the play-off picture means the American is still in contention for the $1million winner's prize.
When asked about what he may spend the money on, Wade made light of the ongoing inflation crisis in the Unites States, saying: "So I think with the million I might fill up my truck with gas, my boat with gas, and we'll see where we're at from there. I may owe them after that."
Wade and Loughnane go head-to-head on August 20 at the Copperbox Arena in London.