In the history of the Professional Fighters League, no one has made as many consecutive semi-final appearances as Wade. The American has been here on three previous occasions, though he is yet to go all the way and get his hands on that $1million cheque.
The 34-year-old, who has been with the organisation since 2018, believes he is in the shape of his life and is determined to prove a point against Manchester's Loughnane.
The pair have gone head-to-head on social media and also took part in a tense face-off ahead of the bout, which will take place on August 20 in London.
"It's a little beyond a point to prove," said Wade in an exclusive interview with Planet Sport. "I mean, Brendan is delusional. The point will be driven home to Brendan once the cage door is shut. It's just to send a message really, that echoes out that I'm the guy. There's no debate about that.
"I'm the [number] one seed. I'm the one who has been here the most times. I'm the guy who was in the finals last year. I'm the guy who has beat Lance Palmer, last year's champ. I'm the guy who finished [Kyle] Bochniak in a minute, who no one else had ever finished.
"It's just about continuing to show the world who I really am. I'm finally growing into my true self in the sport."
Wade started his journey with the PFL in the lightweight division, but moved to featherweight last year and has enjoyed considerable success since.
Throughout his professional career, the American has won 22 of his 29 fights. His most recent victory came in stunning fashion after knocking out Kyle Bochniak, just 70 seconds into the opening round.
The former UFC competitor revealed he hopes to improve with every performance in the octagon, saying: "There's those cliché sayings, but it really is the case, where it's me against me.
"If I can just go back to work and become better than I was the last time, I know that you guys as fans will be really really happy with the body of work you see.
"That's what I look to do every time I get out there now. Just to perform better for you guys."
The fight between Wade and Loughnane will take place at the Copperbox Arena in London, on the same card as Kayla Harrison's lightweight semi-final fight with Czech Republic's Martina Jindrova.