Known for his ability of being both technical and aggressive in the ring, Duran is just the second fighter to have fought in five decades, retiring at 50 after a life-threatening injury.
"Hands of Stone" was part of the most famous rivalry outside of the heavyweight division - later known as the Fabulous Four - which included Sugar Ray Leonard, Marvelous Marvin Hagler and Thomas "Hitman" Hearns.
Duran then beat future champion Guts Ishimatsu and avenged his loss to de Jesus in 1974 via knockout.
"El Cholo" vacated his titles to move up to welterweight in 1979. In total, Duran made 12 lightweight title defences, winning all 12 and 11 coming by knockout.
The Fabulous Four Rivalry
The fight, which originally got announced as a majority decision, is known as the Brawl in Montreal but got turned into a unanimous decision following an error on one scorecard.
Duran - who admitted he had been partying heavily since defeating Leonard in their first battle - shouted 'No Mas' which translated to 'no more' in Spanish during round eight to end proceedings.
Marvelous middleweight challenge
Duran's form inside the ring once he returned dipped, despite winning his next two fights.
His eighth-round knockout of Moore got people talking about Duran again and the Panamanian decided to move up to middleweight to challenge Hagler for the WBA, WBC, IBF, the Ring and lineal belts in 1983.
Malice at the Palace
Retirement, return and Uno Mas
In 1996, Duran tasted a controversial defeat to Hector Camacho for the IBC middleweight title.
Leonard, who was commentating the fight live, called it an early Christmas gift for the Mexican, something which prompted the American to return to the ring in 1997 and face Camacho.
Roberto Duran's net worth
Despite highly lucrative purses against Leonard, Hagler and Hearns, Duran reportedly blew an estimated $20million during the peak of his career through living a lifestyle that consisted of drugs, alcohol and women.