State Farm Stadium in Glendale, Arizona plays hosts as the world turns its eyes to America's sporting pinnacle.
Both sides earned their conference's top seed and first-round bye, with the Chiefs battling through close games against the Jaguars and Bengals to make it to their third Super Bowl in four years, while the Eagles comfortably swept aside the Giants and 49ers by a combined points total of 55.
Fans and pundits are expecting plenty of points in Sunday's affair with the total sitting at 50.5 as the NFL's top two offenses in terms of total yards prepare to face off.
Mahomes' ability to find tight end Travis Kelce early and often will be key to unlocking Andy Reid's offense and with questions marks lingering over the health of the rest of the receiving room, Kelce will have the full attention of the Eagles defense.
Kelce is coming off a regular season in which he finished top 10 in receptions, receiving yards and touchdowns, with no other tight end finishing within 300 yards of the 33-year-old. Now in his ninth NFL season, Kelce has excelled in the playoffs too, accumulating 1,467 yards in 17 games.
Along with quarterback Jalen Hurts, Eagles back Miles Sanders leads the rush attack for Philadelphia, who were the league's fifth-most potent side on the ground this year.
Fresh off a first Pro Bowl selection, Sanders has had his best year as he heads into free agency, earning the fifth-most rushing yards (1,269) and the fourth-most rushing touchdowns (11) in the NFL, both career-highs.
The Chiefs defense features an inexperienced secondary that gave up the most receiving touchdowns in the league this year (33), while nobody gave up fewer yards than Philadelphia through the air.
Despite both offenses' explosive passing potential, the ground game may be the focus for each team with both defenses ranking in the bottom half of the league in opponent yards per carry.
The winner of nine of the last 10 Super Bowls has not trailed at the end of the first quarter or half.
Travis Kelce has a receiving TD in four straight playoff games and has 15 scores in 17 career postseason appearances.
Miles Sanders ranks top 10 in the NFL this year in rushing yards, yards per attempt and touchdowns.
Chiefs To Lead At Half Time & Win The Game In Regulation (Was 2/1 now 5/2).
Miles Sanders To Have Most Rushing Yards In The Game (Was 6/4 now 15/8).
Travis Kelce To Score 2 Or More Touchdowns (Was 5/1 now 6/1).