When: Sunday, May 23, 16:00 BST
How to watch: Sky Sports Main Event
Jesse Lingard has nine Premier League goals to his name since swapping Manchester for East London in January.
With seats on the England coach set to be announced soon, Danny Ings has a crucial chance to further solidify a place under Gareth Southgate.
Teenage striker Ademipo Odubeko is rising through the ranks at the London Stadium.
Moyes' boys on the brink of Europe
Despite missing out on their Champions League dream, West Ham are still in a prime position to finish their season with European football in the bag.
With three points separating themselves and an out-of-form Tottenham, the Hammers can seal their own fate with a victory against the south coast outfit at the London Stadium.
Irrespective of their recent inconsistencies, they will be determined to solidify a place amongst some of Europe's elite.
With 19 more points and six more wins than their aforementioned opponents, the odds will certainly be stacked in West Ham's favour.
After the great successes this season has brought them, finishing it with no fruits to bear for their labour would not be received well in East London. Moyes' boys must ensure this is not the case.
Premier League head-to-head
West Ham wins: 18
Southampton wins: 11
West Ham goals: 55
Southampton goals: 41
Last three Premier League meetings
Southampton 0-0 West Ham (Premier League - December 29, 2020)
As Ralph Hasenhuttl watched on from home via satellite, fans of St Mary's will have wished they could have done the same as a clash on the South coast ended in a 0-0 draw.
With the Austrian manager isolating at home due to COVID safety related issues, his side missed an opportunity to go into the top four.
Despite notable chances from Tomas Soucek and Said Benrahma, neither side were able to mark their influence on the game as a forgettable night came to a close.
West Ham 3-1 Southampton (Premier League - February 29, 2020)
Jarred Bowen justified his 20 million pound price tag on his full debut for West Ham, scoring the goal which sealed the club's first win in two months.
Despite Michael Obafemi leveling proceedings for the visitors, Michail Antonio and Sebastian Haller both made the scoresheet to put the game beyond the reach of Southampton.
The result for the Hammers was welcomed by owners Sullivan and Gold, who had witnessed a number of fan-led protests opposing their ownership of the club.
Southampton 0-1 West Ham (Premier League - December 14, 2019)
In an early relegation clash, a Sebastian Haller goal proved to be the all-important difference maker at St Mary's as West Ham moved up to 15th, easing pressure on manager Manuel Pellegrini.
Saints were out of luck as Danny Ings struck the woodwork twice and had a goal ruled out.
Another loss from Southampton kept them in 18th place, below 17th placed Aston Villa on goal difference.
Strange season for the Saints
From the dizzy new heights of league leaders, to repeats of scarring score lines and an unexpected relegation threat, Southampton's season has certainly been a mixed bag of emotions.
It's difficult for Southampton fans to accurately sum up the past nine months, in what has been an extraordinary campaign in the club's history, for every reason imaginable.
The Saints faithful have rejoiced in wondrous wins - such as their triumph over Newcastle that saw them go top of the table for the first time in the club's history - and a well-earned victory over Liverpool that led an emotional Ralph Hassenhutl to fall to his knees.
On the flip side, the same fans have had to endure yet another 9-0 defeat at the hands of Manchester United. Plus, a number of disappointing defeats in the league since the dawn of the new year - defeats that left them dwindling near the bottom of the table.
As we close out another topsy-turvy top-flight campaign, Southampton's fans, players and certainly their manager will be hoping for a more straightforward season next time out.
West Ham have 19 more points than Southampton, six more wins and have scored 12 more goals than the South coast outfit.
Both teams have been involved in the goals recently, at either end of the pitch.
Six of West Ham's last 10 Premier League games have seen more than three goals scored in them. And the exact same statistic can be taken from the last ten Saints games.