Chris Wood and Jesse Lingard have emerged as pivotal attacking threats for their teams so far this season, with 19 Premier League goals between them - Lingard has been at West Ham since January, making it the more impressive.
David Moyes' side sit 19 points and 11 places ahead of the Clarets and have scored 23 more goals than them this season.
Ben Mee and Tomos Soucek have received eight yellow cards and one red card between them so far this season.
Where can Burnley be better?
Having secured European football and top-half finishes in previous seasons under Sean Dyche - with just five games to go of this current campaign, it's fair to say Burnley haven't enjoyed one of their better spells under his reign.
Following a 10th placed finish last season, the Clarets' currently sit in 16th with 18 less points and have scored 24 less goals, which has somewhat involved them in an unwelcome relegation debate.
Although their emphatic 4-0 victory over Wolves last weekend was instrumental in creating even more breathing room between themselves and Fulham, a closer look at the club's form shows it as only a fourth win in 15 games across all competitions.
A key area that has hindered Burnley this season is their lack of regular goalscorers - with 16 goals between them. Chris Wood and Matej Vydra have scored over half of the team's 30 Premier League goals thus far, with only Jay Rodriguez and Ashley Barnes also managing to score more than two for the Turf Moor outfit.
In addition, inconsistent performances have also plagued Burnley this season, with nine wins, nine draws and 15 losses. The club have failed to sustain promising periods of form throughout the season.
Should they emerge victorious against the high-flying Hammers, safety will be all but solidified for Dyche's side and the door will be open for a late run of wins that could instil some much needed confidence for next season.
Head-to-head in the Premier League
Burnley wins: 5
West Ham wins: 7
Burnley goals: 19
West Ham goals: 19
Last three Premier League meetings
West Ham United 1-0 Burnley
January 16, 2021
An early goal from Michail Antonio proved to be the difference between the two sides at the London Stadium as West Ham moved into the top-half of the Premier League table.
After struggling with a recurring hamstring problem for three months, the English striker marked his return from injury by slotting home Pablo Fornals' cross to put the Hammers ahead.
Despite Burnley threatening to equalise on occasion in the second half through Dwight McNeil, their attacks failed to materialise as Moyes' side emerged victorious in East London.
West Ham United 0-1 Burnley
July 8, 2020
Burnley's Europa League hopes were handed major encouragement as Jay Rodriguez's first-half strike kept Sean Dyche's side within just two points off Arsenal and Sheffield United.
Rodriguez latched on to a superb cross from Charlie Taylor, outfoxing Lukasz Fabianski with a flicked header.
The host persistently pushed for an equaliser but were denied by a string of spectacular saves from Nick Pope, who ensured the score remained in the Clarets' favour.
Burnley 3-0 West Ham United
November 9, 2019
West Ham's woeful winless run under Manuel Pellegrini extended to six games, as a 3-0 win for Burnley saw them move into the top half of the table.
Ashley Barnes put the hosts ahead through Ashley Barnes after just 11 minutes before Chris Wood doubled their lead on the stroke of half-time with an excellent first time shot.
The second half saw a bizarre turn of events in which Hammers' keeper, Roberto dropped the ball into his own goal from an Ashley Westwood corner to further intensify their misery.
An underwhelming display from West Ham saw them fall to 16th in the Premier League table as pressure continued to mount on Pellegrini.
West Ham haven't lost European euphoria just yet
With their remaining five fixtures against teams below them in the table, Moyes' side have a crucial chance to pick up points in their persistent pursuit of Chelsea, as their chase for the Champions League continues.
As a result of the disheartening defeat to the aforementioned Stamford Bridge outfit last week, the Hammers now sit six points adrift of Thomas Tuchel's side in fourth, after occupying a place in the top four for a number of weeks.
Following their brilliant league campaign so far and progressing well in both cup competitions, Moyes was crowned Manager of The Year at the London Football Awards, an accolade very few would have expected the Scotsman to receive upon his return to the East London outfit.
Although West Ham's players, staff and fans alike would have leapt at the chance of Europa League qualification at the start of the season, it is testament to the club that should they achieve that come May, it will feel like a disappointment.
The Hammers' hopes of qualifying for a Champions League may have been tinted slightly, but they are far from over.
Should they be victorious at Turf Moor, this fascinating fight for the top four will continue to roll on.
Jesse Lingard has been a revelation since making a move to the London Stadium, with nine goals in 11 appearances.
Jared Bowen has eight Premier League goals for the Hammers this season, and has proven his worth to Moyes on plenty of occasions.
Chris Wood scored a spectacular first-half hat-trick against Wolves last week, taking the Kiwi's tally to ten Premier League goals this season.