With second place on the line, this could prove to be a massive night for Wales. A win over Estonia would serve as a huge boost to their World Cup qualifying hopes.
Elsewhere, Italy will be looking to end their two-match winless run while Germany target another win under new manager, Hansi Flick.
To celebrate the final night of qualifiers on the European continent, we have picked out six selections with Planet Sport Bet which you can use to form your very own acca.
Don't forget, we also have a fantastic ACCA INSURANCE offer to help you out placing your Wednesday night wagers. This promotion is available to new and existing Planet Sport Bet customers, and full T&Cs apply.
Belarus vs Belgium
Belgium will be looking to take another step towards World Cup qualification when they take on Group E minnows, Belarus.
The Red Devils currently have one of the most emphatic records in this qualifying campaign having won four of their five games; scoring 20 goals in the process.
Belgium's last encounter with Belarus ended in a comprehensive 8-0 win and many are expecting a similar outcome on Wednesday.
The outright market doesn't exactly scream value which is why our first acca bet comes in the handicap market, with Belgium -3 currently offering a juicy price
Hungary vs Andorra
Two teams which suffered England's wrath over the past week will go head-to-head as Hungary host Andorra in Budapest.
Despite their valiant efforts at the European Championships, Hungary are without a win in six games.
Marco Rossi's men followed their recent 4-0 defeat to England with a shock 1-0 loss to Albania - a result which effectively ended their hopes of automatic World Cup qualification.
Nevertheless, this upcoming clash with Andorra is just what the doctor ordered. The last head-to-head meeting ended in a 4-1 win for the Magyars and the hosts are expected to take three more points on Wednesday.
The outright market doesn't offer much value which is why we've delved into the over 3.5 goals bet instead.
Iceland vs Germany
Two games. Two wins. Eight goals scored. None conceded.
Hansi Flick has got off to a strong start as manager of the German national team. His next test sees Die Mannschaft take on Iceland away in Reykjavik.
While the Germans returned to the top of the group, Iceland have dropped to second-bottom and need a miracle to turn things around.
Considering one team is in the ascendancy and the other one is heading in the other direction, the Germans are the ones to back this Wednesday.
Again, there's little to shout about in the outright market so instead, we're backing Flick's men to win both halves.
Italy vs Lithuania
Italy have broken the world record for their incredible unbeaten run. However, since winning the Euros, Gli Azzurri are yet to pick up a victory.
Consecutive draws with Bulgaria and Switzerland leave the European Champions top of their group - at least for now.
Switzerland are four points behind but have two games in hand and they certainly present a serious threat to Italy's hopes of automatic World Cup qualification.
Wednesday's clash against Lithuania presents Roberto Mancini with the perfect opportunity to return to winning ways.
Lithuania have lost all four of their group games; conceding eight goals and scoring one in the process.
With that in mind, Italy to win to nil is our fourth acca addition.
Kosovo vs Spain
Kosovo may be ranked as low as 115th but they're certainly giving this qualifying campaign a good go.
They are currently third in the standings having accumulated four points from four games.
The Scandinavian side are just a point behind the Spaniards with two games in hand. Spain recently lost to the Swedes - a result which significantly impinges on their automatic qualification hopes.
Spain's last meeting with Kosovo ended in a 3-1 victory and a similar result is expected on Wednesday.
Considering Luis Enrique's side have been involved in some high scoring games lately, we're backing the over 2.5 goals bet in our penultimate acca selection.
Wales vs Estonia
It's highly unlikely that anyone in Group E will be able to stop Belgium from taking the automatic World Cup qualification spot.
Rob Page's side have the upper hand despite currently sitting in third. The Dragons are just a point behind the Czechs and have two games in hand.
Wales will be looking to leapfrog their rivals this Wednesday night when they host Estonia in Cardiff.
The Baltic state are currently bottom of the group following their run of three defeats from three games.
Given the visitors' poor form, we can't look past the home side in the outright market.