When: Friday, 30 April, 20:00 GMT
How to watch: Sky Sports
FA Cup finalists Leicester come into tonight's game on the back of three consecutive victories.
A 1-0 win in the FA Cup semi-final against this week's opponents marked the start of this mini-run. The Foxes then returned to league action against West Brom and made light work of their relegation-threatened opponents, securing a 3-0 victory.
Southampton, on the other hand, boast contrasting form having lost three consecutive matches in all competitions. Their 3-0 loss to West Brom was followed by a 1-0 FA Cup semi-final defeat to Leicester.
Last three Premier League meetings:
Leicester City 2-0 Southampton (January 16, 2021)
After both teams had made a good start to the season and both aiming for European qualification, it was Leicester who were victorious in this important clash.
James Maddison found the roof of the net to make it 1-0 from a seemingly impossible angle. The flamboyant midfielder created a 'socially distant' celebration which did the rounds on social media.
Saints tried to respond quickly but Ryan Bertrand's shot was saved by Kasper Schmeichel. The goalkeeper also came to Leicester's rescue by keeping out young midfielder Will Smallbone. Southampton came even closer through Stuart Armstrong when his fierce drive crashed against the crossbar.
Jamie Vardy failed to wrap the game up on the counter attack, however Harvey Barnes showed the former England striker how it's done with a cultured finish in the 90th minute.
Leicester City 1-2 Southampton (January 11, 2020)
In-form Danny Ings fired in his 16th goal in all competitions as Saints gained some payback for their 9-0 drubbing to Leicester only a few months earlier.
A simple attacking move from the home team caught out Southampton as Dennis Praet was left with an easy finish.
Hasenhuttl's men issued a rapid response though, and an ambitious shot from Stuart Armstrong was heavily deflected into the goal to make the scores even after 19 minutes.
Southampton heaped the pressure on and Danny Ings hit the crossbar twice in quick succession. Ings did get his reward late in the game, finishing through the legs of the onrushing Schmeichel to secure his team all three points.
Southampton 0-9 Leicester City (October 25, 2019)
In one of the most incredible matches in Premier League history, Leicester secured the joint-biggest victory in the history of the league and matching a 24-year-old record.
They put nine goals past a dismal Southampton outfit who also had a man sent off. Hat-tricks from Ayoze Perez and Jamie Vardy along with goals from Ben Chilwell, Youri Tielemans and James Maddison helped Leicester to their largest ever margin of victory.
The victory moved Leicester up to second in the table and although on the end of a heavy defeat, Southampton stuck with their manager.
Interestingly, Leicester are 200/1 to repeat that scoreline this weekend.
Premier League head-to-head
Southampton wins: 8
Leicester City wins: 12
Southampton scored: 39
Leicester City scored: 50
In Kelechi Iheanacho, Leicester have arguably the most in-form striker in the league. The former Manchester City starlet has grabbed 14 goals in his last 14 games, including a hat-trick against Sheffield United.
Iheanacho has produced a variety of goals showing that he does have what it takes to be successful in the Premier League and he has been rewarded with a new contract in recent weeks.
His form has been so impressive that it has prompted Brendan Rodgers to change formation, allowing Iheanacho and the evergreen Jamie Vardy to form a formidable strike partnership.
With James Maddison nearing full fitness, he should resume in the attacking midfielder slot for the FA Cup final against Chelsea. Those front three spell danger for any defence in the Premier League and they could be the catalyst for a strong end to the season.
Scoreline prediction: Southampton 0-2 Leicester
There is more riding on this game for Leicester even though Southampton are not mathematically clear of relegation danger. For that reason, there is more incentive for the Foxes to go out and grab the win that would give them a 10-point buffer on fifth-placed West Ham.
The home side might be without Danny Ings which will leave the side without any fire power up front. Leicester themselves are not shy of scoring a goal and have only lost two away games this season.
Kelechi Iheanacho is short odds to score given his recent exploits (best priced 7/5 with Paddy Power) and so it makes sense to look at other potential Foxes goalscorers.
Ayoze Perez scored a hat-trick at this ground in the 9-0 victory over Southampton in 2019 and if Rodgers opts to start the Spaniard, he has a good chance of scoring.
James Maddison will be hoping to prove himself to Gareth Southgate ahead of the Euro's and will want to put in a big performance on Friday.