When: Saturday, April 24, 20:00 GMT
How to watch: Sky Sports Main Event
Brighton are slowly but surely edging towards Premier League safety. Graham Potter's men have picked up nine points from their last five games and the team has built a comfortable cushion above their relegation rivals.
This weekend, the Seagulls can take a huge step towards securing their Premier League status for next season. A win over Sheffield United would move the club up to 14th in the table with five games left in the campaign.
For Sheffield United, this is an opportunity to gather extra points and avoid ending the season with the second lowest points total in Premier League history.
Last Three Premier League Matches
Brighton 1-1 Sheffield United (December 20, 2020)
Despite going down to 10-men, Sheffield United held on for a point away in Brighton.
John Lundstram was shown a straight red card in the 40th minute however, that didn't stop the Blades from taking the lead first.
Jayden Bogle put Chris Wilder's men in front in the 63rd minute as Sheffield threatened to take all three points back to South Yorkshire.
However, a late equaliser from Danny Welbeck, helped the home side to an important point.
Sheffield United 1-1 Brighton (February 22, 2020)
Sheffield took the lead in what proved to be an entertaining first half. Enda Stevens grabbed the opener as the Blades enjoyed a strong start at Bramall Lane.
However, their celebrations were soon cut short as Neal Maupay equalised on the half-hour mark.
The second half produced far fewer chances as the game finished on level terms.
Brighton 0-1 Sheffield United (December 21, 2019)
Brighton dominated possession but ultimately lost the game to a clinical Sheffield United outfit.
The Blades put the ball in the back of the net three times however, VAR ruled two of them out for a handball and offside.
Nevertheless, Oli McBurnie's 23rd minute strike did count and it was the difference maker at the Amex stadium.
Last ten head-to-head games
Sheffield United wins: 5
Brighton wins: 1
Sheffield United goals: 17
Brighton goals: 11
Brighton in-form but with tricky games ahead
If Brighton are to save their Premier League status, a win over Sheffield United is paramount.
Why you may ask? It's simple, look at their remaining fixtures. Brighton will end this campaign with huge games against Leeds, Wolves, West Ham, Man City and Arsenal.
However, with Sheffield United enduring a run of six straight defeats, Graham Potter's side are expected to take all three points back to the south coast.
All about respect for Sheffield United
The lowest ever Premier League points total was achieved in 2007/08 season by Derby County. The Rams ended the campaign with 11 points to their name and only one victory.
The second lowest points total was achieved by Sunderland in 2005/06 when they ended the campaign with 15 to their name.
Sheffield United are currently on 14 points with six games remaining. Question is, can they win two more points and avoid the embarrassment of being the second worst team in Premier League history?
Neal Maupay is Brighton's top scorer with eight goals to his name this season.
However, on this occasion, we're backing Danny Welbeck to get amongst the goals. The former England international may only have four goals to his name, but one of them did come recently away at Old Trafford.