Pep Guardiola's side have won their last 15 games on the bounce - the latest coming against Swansea City in the FA Cup.
The England international will be hoping to continue his recent form against Tottenham, who they face for the 162nd time in all competitions.
The fixture has been relatively even in its history, with both teams claiming wins on 63 occasions; 36 games have ended in a draw.
Jose Mourinho's Spurs have won the last two meetings, something Sterling and co will be looking to change.
Here's a look at the stats that matter.
Sterling has made 16 appearances against Spurs, registering eight goals and three assists.
Spurs are unbeaten against Man City in their last three games, winning two (2-0 on both occasions) and drawing the other.
This season, the Etihad-outfit have averaged 2.12 goals per league games, with the north London club averaging 2.22 goals.
Sterling has eight goals to his name this season in the Premier League, three of which have come in as many games.
Manchester City 2-2 Tottenham Hotspur
17 August 2019
This was the last time that Guardiola's men avoided defeat at the hands of Tottenham.
It was Sterling who opened the scoring in this Premier League classic after 20 minutes. The Englishman headed a scrumptious cross by Kevin De Bruyne past Hugo Lloris to net for the Sky Blues.
Tottenham did however, hit back just three minutes later courtesy of Erik Lamela's 25-yard controlled finish - a shot that caught City 'keeper Ederson off guard.
Aguero restored City's lead going into half-time after converting De Bruyne's low cross but Spurs would respond in the second-half with Lucas Moura - who is responsible for one of the defining moments in European football history - headed home Lamela's inviting corner.
Despite VAR controversy in stoppage time, the game would end 2-2, a result which contributed to Man City surrendering the Premier League title to Liverpool.
Manchester City 4-3 Tottenham Hotspur
17 April 2019
UEFA Champions League
This was a night that will be remembered for the wrong reasons for those with a Man City allegiance.
Going into the second-leg of the quarter-final tie, Spurs had a slender lead after winning 1-0 at the Tottenham Hotspur Stadium. As expected, City came firing out and levelled the aggregate score thanks to a tidy finish from Sterling.
Spurs responded instantly with two goals in 10 pulsating minutes of action. Both goals came from the right boot of Heung-min Son; firstly managing to slip a driven shot under Ederson, and secondly crisply curling a shot from the edge of the box and into the top corner.
The game changed complexion again just one minute later, this time with Bernado Silva's effort deflected off Danny Rose to equalise for City. Sterling grabbed a second to swing the pendulum back in the favour of Guardiola's side to make it 3-2 on the night, and 3-3 on aggregate.
Aguero looked to have sealed City's progress in the competition after firing home in the 59th minute but there was still time for one more twist. Fernando Llorente ended Guardiola's hope of a historic quadruple, scoring from Kieran Trippier's corner.
Sterling thought he had won it for City in injury time only for VAR to rule it out for offside. Spurs went on to reach the final, but were beaten 2-0 by Jurgen Klopp's Liverpool.
Tottenham Hotspur 1-3 Manchester City
14 April 2018
City were in fine form on this night as they marched towards their third Premier League title, and a first for Guardiola.
Jesus opened the scoring after 22 minutes before doubling their lead with Ilkay Gundogan netting from the penalty spot.
Christian Eriksen offered some hope for the hosts on the stroke of half-time, when his initial blocked shot ricocheted off Aymeric Laporte before back onto the Danish playmaker and past Ederson.
It was Sterling who made the final stages comfortable for City, as he slammed the ball home from close range after Lloris could only parry a shot at the feet of the Englishman from Jesus' original shot.
Man City went on to break the record for the most points in a Premier League season with 100 points.
Tip for the Fixture
Sterling is in scintillating scoring form and he could make you look silly if you back against him. The 26-year-old is 11/10 to score at any time with Paddy Power (price correct at the time of writing but could change).