Thomas Tuchel's men are currently top of the table and a win over the Foxes will give them a six-point cushion over the chasing pack.
Leicester, on the other hand, have endured a stuttering start to the season and entered the international break in the bottom half of the table. However, a win over the Blues could spark a turnaround in fortunes.
When, where and how to watch
When: Saturday, November 20, 12.30 GMT
Where: King Power Stadium
How to watch: BT Sport
Best bets for Leicester vs Chelsea
You could argue that the international break came at just the right time for Chelsea. The team's lengthening injury list was beginning to take its toll on the pitch - an argument backed up by their 1-1 home draw against Burnley last time out.
The break also means that Tuchel's men will be fresh and far better equipped to tackle a tricky run of games.
The Foxes, meanwhile, have their own problems. After two successive seasons of fighting for Champions League soccer, reality has slowly but surely began to catch up with Leicester.
Brendan Rodgers and his men have won just four league games this season and are currently sitting 12th in the standings.
Leicester boast an impressive recent record against Chelsea but considering their defensive woes, we're backing the visitors to bag a late win at the King Power.
Three of Chelsea's last four away victories have been level at the bereak. With that in mind, there's value to be found in the half-time/full-time market.
Last three meetings
Chelsea 2-1 Leicester (Premier League - May 18, 2021)
After a goalless first half, fans were forced to wait until after the interval to finally catch some action.
Antonio Rudiger opened the scoring in the 47th minute before Jorginho doubled Chelsea's lead with a well converted penalty.
Kelechi Iheanacho grabbed a contact goal late on but it wasn't enough to stop the Blues from taking all three points.
Chelsea 0-1 Leicester (FA Cup Final - May 15, 2021)
Three days before their Premier League clash, the two clubs met at Wembley in the 140th FA Cup final.
On this occasion, it was the Foxes who celebrated the win thanks to a second-half wonder goal from Youri Tielemans.
The win sealed Leicester's first ever FA Cup trophy.
Leicester 2-0 Chelsea (Premier League - January 19, 2021)
Frank Lampard's last Premier League game in charge of Chelsea ended on a disappointing note.
Goals from Wilfred Ndidi and James Maddison helped Leicester to a memorable 2-0 victory at the King Power.
Lampard took charge of an FA Cup game against Luton a few days later before the axe fell.
Chelsea's love of away trips
We're still a couple of months short of celebrating Thomas Tuchel's first year as Chelsea manager but it's fair to say that the German has taken Stamford Bridge by storm.
One of the most impressive stats during his tenure is that fact that Chelsea have only lost three away games in all competitions.
Out of 22 away outings, Tuchel boasts a record of 15 wins, four draws and three losses. Two came at the hands of Juventus and Aston Villa, while the defeat to Leicester in the FA Cup final was more neutral venue than away.
Looking at the outright odds, the bookmakers are expecting Chelsea to continue their fine away form. However, considering three of their last four trips all ended with a 1-0 scoreline, we're not expecting this to be a goal-fest.
Our second selection is to back under 2.5 goals. Interestingly, this same bet landed in six of the last eight head-to-heads.
Last 10 head-to-heads
Leicester wins: 3
Chelsea wins: 3
Leicester goals: 9
Chelsea goals: 7
Leicester able to frustrate
The situation isn't all that bad at Leicester. In fact, a win over Chelsea would see the Foxes leapfrog Manchester United into sixth.
Rodgers may not have racked up the wins this season but Leicester deserve a lot of credit for frustrating their opponents.
Chelsea certainly know all about that having won just one of their last seven Premier League encounters against Leicester.
Games between the two have been closely contested in recent years. What's more, most of them tend to be decided in the second half.
Looking at the last eight head-to-heads, there's been a total of 14 goals scored. Incredibly, 11 of them have arrived after the interval.
Bearing that in mind, our third selection is to back the second half to have the most goals at 11/10.
Goalscorer bets for Leicester vs Chelsea
Vardy's goalscoring rate against Chelsea doesn't hit those same heights, having netted four times in 17 games. Nevertheless, he will be a popular selection at 11/5.
With regards to Chelsea, it's Romelu Lukaku who leads the anytime goalscorers market at 11/10.
However, with the Belgium international returning from injury, this might be the perfect opportunity to look elsewhere.
For instance, Kai Havertz looks like a steal at 2/1. The 22-year-old has scored five goals from his last nine appearances for club and country.