When: Saturday, March 13, 20:00 GMT
How to watch: BT Sport
City storming on towards title
While their egos may have been slightly bruised after losing to local rivals Manchester United last weekend, in all likelihood that defeat is going to be but a mere blip in Manchester City's romp towards the Premier League title.
If their starting line-up in any given game isn't enough for teams to contend with, their excellent record with injuries this season has meant their bench is just as fearsome.
Their record-breaking winning streak has led City to a completely dominant 14-point lead at the top of the Premier League.
Where the Premier League trophy ends up isn't so much of a proposition as 'wheref' as a 'when, and by how big a margin?'
Last three Premier League meetings:
Manchester City 2-0 Fulham (December 5, 2020)
In the reverse fixture three months ago, City edged their way to a 2-0 win after a masterclass from Kevin De Bruyne.
He assisted the opener when a quick break saw the Belgian slide through a pass to Raheem Sterling, who slotted into the far corner with ease.
De Bruyne then got on the scoresheet himself when he sent Alphonse Areola the wrong way from the penalty spot.
Fulham 0-2 Manchester City (March 30, 2019)
Fulham were on their way to relegation back in 2019, before a solitary season in the Championship saw them jump straight back into the top flight for this season.
Manchester City were out of sight in this match within half an hour, though, after Bernardo Silva's opener after five minutes was added to by Sergio Aguero, before City were able to see out a comfortable victory at Craven Cottage.
Manchester City 3-0 Fulham (September 15, 2018)
Another encounter where City put the result beyond doubt quickly after a fast start in this one. Leroy Sane notched the opener with a only a minute on the clock to sink Fulham's early enthusiasm.
David Silva added a second midway through the second half, while any hopes of a second-half comeback for Fulham were quashed quickly as Raheem Sterling scored City's third less than two minutes after the second period began.
Another comfortable day from a Manchester City standpoint.
Head-to-head in the Premier League
Fulham wins: 4
Manchester City wins: 14
Fulham scored: 31
Manchester City scored: 58
Can Fulham get their heads above water?
A fantastic win against Liverpool at Anfield confirmed to the rest of the Premier League that, of the teams in the bottom three, Fulham are the most likely to claw themselves to safety.
Scott Parker's side have been on an upward trajectory for several weeks now. It wasn't a particularly hot take to say that Fulham's style of play merited better results throughout the season, but their form is slowly beginning to reflect their early-season promise.
After their win on Merseyside, they have now drawn level on points with Brighton and Hove Albion in 17th, so any positive result could see Fulham climb out of the bottom three for the time being.
Motivation won't be an issue for Saturday night's meeting with City, but their task to get points will be the toughest possible test in English, and possibly European, soccer at the moment.
Even with their improved form in the Premier League, it's hard to see beyond a comfortable Manchester City victory on Saturday evening.
Although Fulham were a Championship side for a couple of their recent meetings, they have failed to score a single goal against the champions-elect in their last six match-ups in all competitions against Guardiola's men.
Of course, the Cottagers will look to cause an upset, but it's looking unlikely at this point.
With City's rotation policy meaning that seemingly no player is a guaranteed starter, anytime goalscorer bets may be the way to go for this one.
(All prices correct at time of writing, subject to change).