Elsewhere, Borussia Dortmund will be looking to get their Bundesliga campaign back on track with a game against Hoffenheim, and Juventus will have their eyes on all three points as they travel south to face Napoli. Welcome to Weekend Watch.
Leicester City v Liverpool (Premier League) - Saturday 12:30 GMT
What a way to open up the weekend! Leicester manager Brendan Rodgers welcomes his former employers to the King Power Stadium for a much anticipated Saturday lunchtime clash.
The Foxes have a poor home record against Liverpool having lost their last three meetings. However, with the Reds stuck in a rut, this could be their opportunity to end that sequence.
A win for the hosts will condemn Liverpool to three consecutive league defeats - something they haven't done since the tenure of Rodgers himself.
The Reds are the bookies' favourites to win this game but considering the level of unpredictability this season, don't be surprised if it goes the other way.
Borussia Dortmund v Hoffenheim (Bundesliga) - Saturday 14:30 GMT
Out of form. Out of the top four. And without a proper manager. This is the reality for Borussia Dortmund as they look to try and rescue their faltering season.
A 2-1 loss to Freiburg last weekend was Dortmund's eighth defeat of the season. The last time they had lost so many games at this stage of a season was back in 2014/15 - they finished the campaign in seventh place that year.
Hoffenheim aren't in great form themselves. However, with everyone taking points off Dortmund, Die Kraichgauer will feel like they can do the same.
Paris Saint-Germain v Nice (Ligue 1) - Saturday 16:00 GMT
One of the most exciting title fights across Europe is currently taking place in Ligue 1 where Lille, Lyon and PSG are separated by three points with only 14 games to go.
Mauricio Pochettino's men could pile the pressure on their opponents this weekend when they take on Nice.
The visitors may be a mid-table club. However, they do boast one of the best away records in the division and could still prove to be a threat.
PSG's star power should get them through this but it won't be a walk in the park.
Napoli v Juventus (Serie A) - Saturday 17:00 GMT
One of the headline games this weekend takes place at the Stadio Diego Armando Maradona with Napoli set to host Juventus.
Two defeats from three games have all but ended Napoli's title ambitions. Nevertheless, Gennaro Gattuso's men are still battling for a top-four finish.
Juve, on the other hand, have experienced a massive improvement in form and find themselves well in the hunt for another Serie A title. A win here will put them within four points of league leaders AC Milan.
There is a lot at stake in this fixture but an in-form Juve should do the business.
Manchester City v Tottenham (Premier League) - Saturday 17:30 GMT
If you can only watch one game this weekend, make sure it's this one.
But let's be honest. This game is less about City v Spurs and more about Guardiola v Mourinho. The two managerial titans have been battling for over a decade. The Spaniard had the edge in the early days of this rivalry. However, the Special One has won four of the last seven encounters. In fact, he could become the first man to beat Guardiola away from home for a third time.
Who wins this Saturday I hear you ask? In normal circumstances, City walk all over Spurs. But these are far from normal circumstances so don't be surprised if you see a bit of the old Mourinho magic on show.
Spezia v AC Milan (Serie A) - Saturday 19:45 GMT
AC Milan's pursuit of their first Serie A title since 2011 continues with an away clash against Spezia.
Stefano Pioli's men have claimed 49 points so far this season, becoming only the 18th team to ever reach this mark after 21 Serie A games. The good news for I Rossoneri is that 14 of those sides have gone on to win the title.
Spezia, however, will not be easy opposition. The newly promoted side are coming into this game on the back of a 2-1 win over Sassuolo and they could give AC Milan a run for their money.
Barcelona v Alaves (La Liga) - Saturday 20:00 GMT
Kevin Keegan's famous words "we're still fighting for this title" would certainly ring true around Camp Nou today. It's been a difficult season for the Catalonian giants. However, Ronald Koeman's men have won six straight league games and they're closing the gap to leaders Atletico Madrid.
This Saturday night, Barca take on Alaves in a game they have to win if they are serious title challengers.
Barcelona have won eight of their last nine games against Alaves and they're good enough to keep that run going this weekend.
West Brom v Manchester United (Premier League) - Sunday 14:00 GMT
Believe it or not, Manchester United haven't completed a season double over West Brom since the 2011/12 campaign. There have been 13 games between the two clubs since then and the Red Devils have only managed six victories.
Unfortunately for the Baggies, the stats won't matter this Sunday afternoon. Sam Allardyce's men have been absolutely woeful and have only managed to win one point from their last five Premier League games.
Even parking the bus may not be enough to stop a bloodbath.
Real Madrid v Valencia (La Liga) - Sunday 15:15 GMT
It's been 53 long years since Valencia last completed a season double over Real Madrid. This Sunday, the club have an opportunity to bring that run to an end thanks to a 4-1 win over Los Blancos earlier this season.
For Zinedine Zidane's side, this is a game they simply can't afford to lose. Real Madrid are five points behind league leaders Atletico Madrid and any dropped points will simply push their neighbours closer to the title.
Nevertheless, Real Madrid v Valencia is a fixture that rarely disappoints and always delivers a shedload of goals.
Inter Milan v Lazio (Serie A) - Sunday 19:45 GMT
From one classic fixture to another.
Antonio Conte's men are currently second and two points behind their city rivals. The problem is that their upcoming opponents, Lazio, are the most in-form team in the league.
Simone Inzaghi's men have won six straight league games and they offer great value in the betting to maintain that run this weekend.
Strap yourselves in, this will be a good one!