Jurgen Klopp's squad will be hoping to bounce back from their loss at the hands of bitter rivals Everton last weekend, which marked a fourth straight league defeat for the reigning champions.
The Toffees took the lead after just three minutes through their Brazilian striker Richarlison, and a controversial 83rd-minute penalty converted by Gylfi Sigurdsson earned Everton their first win at Anfield in 22 years.
The Reds will now be hoping to turn their fortunes around against bottom-placed Sheffield United, who have just three league wins all season.
Liverpool may have conceded 10 in their last four Premier League games, but they will take confidence knowing they have not conceded to the Blades from open play since January 2003 in the League Cup semi-final first leg, which ended 2-1 to Sheffield United.
Mo Salah has featured in all three of these meetings, but has just one goal to his name against them.
Let's take a look at how Salah did in these three games:
Sheffield United 0-1 Liverpool
Premier League, Bramall Lane
28 September 2019
A 70th-minute Georginio Wijnaldum goal was all that separated the two sides when they last met at Bramall Lane in 2019.
The goal described as 'lucky' by Klopp came as a weak volleyed effort from outside the box crept through the hands of 'keeper Dean Henderson, gifting Liverpool the lead.
The victory was Liverpool's seventh league win in as many games, giving them the perfect start to the season and a five-point lead at the top of the table.
Despite playing the full 90 minutes, Salah struggled to make an impact from the right-hand side, and missed a decent opportunity to double his side's lead when one-on-one with Henderson.
Salah had a total of four shots at goal in this game, and earned just a 6.5 match rating on WhoScored.com.
Liverpool 2-0 Sheffield United
Premier League, Anfield
2 January 2020
At Anfield, Liverpool dominated every aspect of the game to cruise to a 2-0 win over Chris Wilder's men.
The Egyptian winger gave his side the lead after just four minutes as he turned in an Andy Robertson cross from close range.
This goal meant Salah had now scored against 22 of the 25 Premier League opposition clubs he had faced, failing to score against Aston Villa, Swansea and Manchester United.
Salah also played a major role in the second goal, as his through-ball split the Blades' backline and was converted by Sadio Mane on the second attempt.
The match not only put Liverpool one step closer to Premier League glory, but also marked a full year without losing in the top flight.
Liverpool 2-1 Sheffield United
Premier League, Anfield
24 October 2020
In the reverse fixture this season, Liverpool once again earned themselves all three points despite falling behind early on.
Salah was the frontman of an attacking 4-2-3-1 formation, and his side had to dig deep to comeback after the opposition took the lead through a 13th minute penalty.
A Roberto Firmino strike just before half time levelled the scoring, and a 64th minute header from new signing Diogo Jota completed the comeback in what was Liverpool's first league game without Virgil van Dijk in 75 matches.
Whilst he didn't get his name on the scoresheet, Salah still had a strong game, having four efforts at goal.
Salah also earned himself the third-highest player rating on BBC Sport with 7.38, behind Mane (7.43) and Jota (7.58).
Tip for the fixture
With Liverpool out of form another upset could be on the cards, and Sky Bet are offering odds of 19/5 for this game to end as a draw.
(Odds are correct at time of writing, subject to change).