The Galaxy, led by Javier Hernandez, go on the road in this fixture, and they struggled at Seattle earlier this season but are in second place in the Western Conference with 12 points.
Portland have lost three straight, but they did manage to get striker Jeremy Ebobisse (concussions) back into the starting line-up for the last two games. He has yet to find the net this season, and midfielder Sebastian Blanco (knee) remains out.
Chicharito leads the league with seven goals on the season, and he is 13/10 as an anytime goalscorer with Paddy Power. He has added two assists in five games and has only been shut out by opposing defences once all season.
Last year when these teams played, there were 24 goals scored in four games between these teams, three won by Portland. According to Paddy Power, the Timbers are 4/5 to win while the Galaxy are 3/1 and a draw is 27/10.
Miami aiming for another victory on the road
Phil Neville and Inter Miami won on Sunday and look to make it two in a row with a trip to last-place Chicago Fire this weekend. Gonzalo Higuain scored twice in the Sunday win at FC Cincinnati, including the game-winner, and he is 6/5 as an anytime scorer against Chicago.
Miami have not lost on the road this season with two wins and a draw. Higuain tallied goals against the Galaxy and Philadelphia before his brace in Cincinnati.
The Fire have four straight losses coming into this match, and they are last in MLS in goals scored through five games. Chicago have conceded 10 goals this season and their only point came from a 2-2 draw against New England after they blew a 2-0 first-half lead.
Nani leads Orlando City against Toronto
Former Manchester United star Nani is on fire early this season, with a string of impressive goals to lead Orlando City up the Eastern Conference table. This week the Lions take on homeless Toronto FC, who are still trying to get things going under new manager Chris Armas.
Orlando have been without Alexandre Pato, and Nani leads the way with three goals while Chris Mueller has two assists. The Lions have just two wins in 12 games against Toronto, though the teams have not met since 2019. Goalkeeper Pedro Gallese has three clean sheets in the season so far, with just two goals conceded and 11 saves.
Toronto have looked lost at times without former MVP Alejandro Pozuelo, and now Jonathan Osorio is doubtful as well. With Pozuelo out, striker Jozy Altidore played as an attacking midfielder against NYCFC last week and could be in that role again at Orlando. Dom Dwyer made his debut for TFC last week and now returns to face his former team.
(All odds correct at time of publication, subject to change).