We start the weekend with the indomitable Bavarians. Hansi Flick's men take on an in-form VfB Stuttgart side in the Südderby - otherwise known as the 'Southern derby'.
There are two things we definitely know about this fixture. A - there's always plenty of goals. And B - Bayern win 94% of the time.
Over the past decade, there have been 18 games between the two clubs and Der FCB have won 17 of them.
Borussia Dortmund's race for the top four continues this weekend against relegation threatened FC Koln.
BVB have won three of their last four Bundesliga games and they're the overwhelming favourites to take all three points this Saturday.
FC Koln have lost for of their last five games and are without a win since early February. Rumours have it that Markus Gisdol will be sacked should his side lose against Dortmund. I wonder whether he's packed his suitcase yet?
After getting the job done in the Champions League against Atalanta, Real Madrid turn their attention back to the title race.
This weekend they take on a Celta Vigo side which is looking to make a late push for Europa League places. Eduardo Coudet's men have lost just one of their last eight games and they are capable of frustrating Los Blancos.
The stakes are high but Zinedine Zidane's men should have enough fire power to get the job done. Real have won four of their last five games against Celta by a two-goal margin and there's no reason why they couldn't do so again.
Over the last three years, this fixture has been one to dread for Toffees supporters. City have won six straight games with the Merseyside club - winning four of them by the same 3-1 scoreline.
Everton come into this on the back of successive league defeats and they don't currently look like a side who could threaten City's dominance.
Los Millonarios currently sit sixth in Group A of the Copa de la Liga Profesional however, a victory could take them into the top four.
With five consecutive head-to-head wins, River Plate are expected to take all three points back to Buenos Aires.
With Rangers having already wrapped up the league title, this upcoming Old Firm derby is all about pride and Glasgow supremacy.
Steven Gerrard's men endured an awful night against Slavia Prague this past midweek with allegations of racism and post-match confrontation taking all the headlines.
Celtic will know that and they'll be aiming to become the first team to beat Rangers this league season. As always, a close contest is expected and backing a draw is the sensible way to go.
Two teams on the opposite ends of the form spectrum go head-to-head as Chelsea welcome Sheffield United to Stamford Bridge.
While the Blues are in the 'Champions League winning' conversation, the Blades seem to have waived the white flag in their 5-0 loss to Leicester City last weekend.
I'm afraid it's not a case of 'if' Chelsea win but rather it's a question of how many they'll score.
Andrea Pirlo has 12 games left to save Juve's season... and potentially, his job.
After crashing out of the Champions League, all the focus has turned to defending their Serie A crown. The problem, however, is that current leaders Inter are ten points ahead and are in the midst of an eight-match winning run in the league.
Benevento are out of form and Juventus have enough star power to take all three points. Cristiano Ronaldo scored a hat-trick last weekend and he's well priced to get amongst the goals again.
The Foxes have endured a poor run of results against United and they haven't beaten them since that 5-3 classic back in 2014.
Bearing in mind the recent head-to-head record and United's strong away form, the Red Devils are our pick to win.
Just a few months ago, AC Milan were the talk of the town. But in a short space of time, this notion has found a dead end. I Rossoneri are currently out of the Coppa Italia, out of the Europa League and now, potentially out of the title race.
Stefano Pioli's men have buckled at the business end of the season and could end a promising season with nothing to add to the trophy cabinet.
With 11 games remaining in Serie A, AC Milan must put a winning run together if they are to challenge Inter. However, in their current form, we don't think they can even beat Fiorentina.
The wheels are coming off Atletico Madrid's season. The question is, can they find a quick fix and save their La Liga title ambitions?
Atletico simply have to win this upcoming game against Alaves and stop the rot.
If Mauricio Pochettino wants to finally win a league title, his men simply have to win all three points this weekend.
The Ligue 1 title race couldn't be more finely poised with both PSG and Lyon trailing league leaders Lille by three points with just nine rounds left.
This feels like a pivotal moment in the season and the result of this game could shape the remainder of this race. PSG are the favourited but all in all, this is too close to call.
The weekend comes to an end with what is shaping up to be a highly entertaining game in La Liga.
Real Sociedad are missing a number of players due to injuries however, they're still well in the fight for a European qualification place.
Lionel Messi and co need to win this weekend in order to stay within touching distance and considering their recent form, they should be able to get the job done.
Generally speaking, Barca could still end the season with a league/cup double. That would be some achievement taking into account the many off-field issues.