A 3-2 win in the opening leg means Borussia Dortmund have a slight advantage over Sevilla heading into Tuesday's rematch - a similar scenario to last weekend's Der Klassiker.
BVB raced to a 2-0 lead last Saturday but only briefly enjoyed their advantage as Bayern produced an incredible comeback to win 4-2. Could we see a similar downfall against Sevilla?
Based on recent results, it's not likely. Sevilla have gone from being one of the most in-form teams in Europe to having lost four of their last five games.
With that in mind, back Dortmund to progress.
Juve seem to have found their scoring boots in recent games having bagged 10 goals in four matches. The majority of those goals came from Alvaro Morata and Cristiano Ronaldo; two men who will play a pivotal role if Andrea Pirlo's men are to progress in the Champions League.
FC Porto take a 2-1 aggregate lead into Tuesday's rematch however, their record away in Turin won't fill them with much confidence.
Their last two visits both ended in defeat and it's no surprise that the bookies are backing the Italians to progress.
There were two significant results over the weekend. The first was Southampton's victory over Sheffield United; their first league win in 10.
Will these two big results have an impact on this Wednesday's encounter? Probably not. City have won their last four games against the Saints and Pep Guardiola's men will be desperate to return to winning ways.
The La Liga title race has now been closed down to just three points. Atletico's 1-1 draw in the Madrid derby has allowed Barcelona to close the gap and an exciting finish to the season is well on the cards.
This midweek, Atletico have an opportunity to use their game in-hand to pull away from the Catalonian giants - however, that is a lot easier said than done.
Their opponents, Athletic Bilbao, are on an eight-match unbeaten run in all competitions and they will give the Madrid outfit a run for their money.
After a torrid league run, Liverpool will welcome a return to Champions League action this Wednesday night.
Jurgen Klopp's men have a 2-0 aggregate lead over RB Leipzig heading into the second leg and the bookmakers seem confident that the Reds will progress.
The question is, why are the bookmakers so confident? Liverpool's run of six defeats from eight games certainly doesn't exude confidence. Neither does Leipzig's run of four straight wins; in which they've scored 11 goals and conceded just two.
The Germans are well priced to win the second leg however, our recommendation is to go further and back Leipzig to win the tie.
They say lightning doesn't strike twice. We disagree.
This time, the Parisians are 4-1 up. Could Barca pull off another remarkable comeback?
The bookmakers are backing PSG to win this game and why shouldn't they? Afterall, Pochettino's men are in great form having won three straight games.
However, this is the Champions League; a competition where anything could happen.
Barca's remarkable comeback in the Copa del Rey against Sevilla last week suggests they are up for a fight. With that in mind, we're backing Koeman's men to deliver an almighty shock.
Nevertheless, United come into this game on the back of a huge victory in the Manchester derby last weekend. Ole Gunnar Solskjaer's men haven't lost since January and they're odds on to continue that run against AC Milan.
Just over a year ago, Olympiacos came to the Emirates and scored a 120th minute extra-time winner to send Arsenal out of the Europa League.
Could the Greeks pull off another famous win over the Gunners? Why not? Olympiacos are flying in their domestic league and have a host of talent across the park.
Arsenal, on the other hand, have lacked consistency throughout the course of the season. Four wins from 10 games in all competitions doesn't make good reading.
Two in-form teams will go head-to-head in London as Spurs host Dinamo Zagreb in the first leg of their Europa League Last 16 tie.
Jose Mourinho's men have won four straight games in all competitions and managed to bag four goals in three of those fixtures.
Dinamo, on the other hand, are in the midst of an eight-match winning run and could prove to be dangerous.