Jamie Vardy and Kelechi Iheanacho have scored 28 goals between them so far this season.
Leicester City's strikers to each have 2+ shots on target is 9/2 on Paddy Power.
The last three meetings between the two sides have produced 14 goals, and this fixture is likely to produce more.
James Ward-Prowse and James Maddison are two players renowned for their goal threat via set-pieces and long range strikes.
The two midfielders to have two or more shots from outside the box each is 11/2 on Ladbrokes.
Southampton's route to the final four
Despite a disappointing second-half of a season that has seen them rejoicing as league leaders to dwindling in the bottom half of the table, Southampton's immaculate run in the cup competition is an undeniable positive of an erratic campaign for the South-coast club.
In addition to four impressive victories en route to the semi-finals, the Saints have reached the final four of the competition without conceding a single goal - a terrific achievement should they be able to go all the way.
After comfortably dispatching of Shrewsbury Town 2-0, Hasenhuttl's side fended off stiff opposition from Premier League sides in the fixtures that followed, beating Arsenal 1-0 and bettering Wolves 2-0 before a superb three-goal victory over Bournemouth at the Vitality Stadium.
With their opponents embroiled in a fierce fight for the top four, Southampton have an invaluable opportunity to reach their first cup final since the 2017 EFL Cup final against Manchester United.
If the St Mary's outfit can add valuable silverware to their trophy cabinet, recurring demons of a lacklustre league campaign will be all but diminished.
Last three meetings
Leicester 2-0 Southampton (January 16, 2021)
Leicester maintained their position in the top four with a hard-fought win at the King Power to go second in the table, earlier this season.
Despite Southampton having a lot of the ball, the home side broke the deadlock through James Maddison - who fired home from an acute angle to give the Foxes a 1-0 lead going into half-time.
After a closely contested second half, Harvey Barnes grabbed a second for the hosts five minutes into injury time, to solidify a successful evening for Leicester.
Leicester 1-2 Southampton (January 11, 2020)
A late winner from Danny Ings saw Southampton come from behind to secure a deserved 2-1 victory on the road.
The game got off to a lively start with two goals in the opening 20 minutes - Dennis Praet put the Foxes in front before his effort was cancelled out just five minutes later by a deflected strike from Stuart Armstrong.
Grabbing a deserved goal in a match where he caused a number of problems for Southampton, Ings - who has been linked with a move to Manchester City - redeemed a number of near-misses by emphatically snatching a winger for Hasenhuttl's men.
Southampton 0-9 Leicester (October 25, 2019)
A south coast shambles for the Saints saw them equal an unwanted record for the heaviest defeat in Premier League history. Their 9-0 hammering was the first result of its kind since Manchester United's win over Ipswich in 1995.
Two hat-tricks from Ayoze Perez and Vardy alongside goals from Maddison, Ben Chilwell and Youri Tielemans easily wrapped up an emphatic victory at St Mary's for Brendan Rodgers' side, who went second in the table.
Having gone a goal up after just ten minutes, the Foxes were further aided by the dismissal of Ryan Bertrand, enabling the floodgates to open as Southampton completely capitulated in front of their astonished home crowd.
A night to forget for the Saints saw Leicester record the biggest ever victory by an away side in an English top-flight league match in the 131-year history of the Football League. It also inflicted Southampton's biggest ever defeat in their stint as an English league side.
(Previous ten meetings in all competitions)
Leicester wins: 5
Southampton wins: 3
Leicester goals: 20
Southampton goals: 9
Leicester's journey to the semis
Sitting third in the Premier League with only a handful games to go having additionally reached the final four of the cup, Leicester are continuing to revel in a glorious period of football under Rodgers.
Much like the aforementioned cup run of their opponents, Leicester's journey to the semi-finals has also occurred in impressive fashion.
Leicester breezed past Stoke 4-0 in the third round, defeating a fearless Brentford team and a resolute Brighton side before most notably dismantling Manchester United 3-1 in a stellar performance at the King Power.
A strong finish to a hard-fought Premier League campaign combined with a euphoric cup win can propel Leicester to unimaginable heights as Rodgers' revolutionary tenure rolls on.
Danny Ings has scored nine goals in all competitions so far this season.
Jamie Vardy has 5 goals against Southampton in 13 appearances across all competitions.
Vardy to score, 4+ corners each team and Ndidi to be carded is 25/1 on Sky Bet.
Southampton have scored in both the first half and second half in 35% of their Premier League fixtures so far.
Hasenhuttl's side to score in both halves is priced at 5/1 on Ladbrokes.