Having already won the two biggest European club competitions, Jose Mourinho will eye his third as he looks to take Roma into the Conference League group stages.
Ahead of Thursday's games, we have picked out six bets - including one in Roma's clash against Trabzonspor - to help you put together your accumulator.
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Alashkert vs Rangers
Following their Champions League exit, Rangers are looking to bag a spot in Europe's second tier competition.
The Scottish champions are just 90 minutes away from doing just that as they look to capitalise on their 1-0 first-leg advantage over Armenia's Alashkert.
Since their defeat to Malmo, Rangers have recovered well, winning three straight games - scoring ten goals in the process.
Prevailing away in Armenia will be no easy task but considering Alashkert have only managed one win in eight games, the Scots are rightfully favourites.
Our tip is to back Steven Gerrard's side in the outright market.
AZ Alkmaar vs Celtic
From one Glasgow outfit to another, Celtic will also seek Europa League qualification when they take on AZ Alkmaar at the AFAS Stadium.
The Scots have a 2-0 lead going into the second leg, meaning they're in pole position to qualify for the group stages.
Despite some tough results at the start of his reign, Ange Postecoglou's side have really kicked into gear over the last few weeks. Celtic are currently on a six-match winning run, scoring 24 goals in the process.
With the Dutch side needing to attack and the Scots scoring goals for fun, our tip is to back the draw and both teams to score.
AS Roma vs Trabzonspor
Jose Mourinho is a Champions League winner. Jose Mourinho is a Europa League winner. Question is, can Jose Mourinho become a Europa Conference League winner as well?
The Portuguese manager can take a big step towards making that happen when AS Roma look to seal their place in the competition.
The Italian outfit are currently 2-1 up against Turkey's Trabzonspor with the second leg taking place in Rome.
Roma have only lost three games at the Stadio Olimpico this calendar year and we don't expect that number to increase on Thursday evening. As a result, the hosts are the team to back in the outright market.
St Johnstone vs LASK
St Johnstone will be looking to make the group stages of a European competition for the first time in their history when they take on LASK Linz.
The tie is finely poised following their 1-1 draw in the opening leg. However, even with the Saints playing on home turf, the bookmakers are favouring the Austrians to progress.
A lot of that could be down to St Johnstone's woeful run of results at home. Callum Davidson's side haven't won a game at McDiarmid Park since April, while their last two games there both ended in defeat.
With that in mind, we're backing the visitors to do the business and deny St Johnstone an historic moment.
Aberdeen vs Qarabag
It's been 13 years since Aberdeen last played in the group stage of a European competition.
Back then, the Dons were in the UEFA Cup and even managed to progress out of their group - which included Atletico Madrid. Their journey ended with a 7-3 aggregate loss to Bayern Munich in the following round.
The Scots have an opportunity to create new European memories but first they must overturn a 1-0 deficit from their first leg clash against Qarabag.
The Azerbaijan outfit are no strangers to European soccer having qualified for either the Europa League or Champions League group stages seven years in a row.
That level of experience can go a long way and our tip is to back the visitors. After all, Aberdeen's three-match winless run is hardly convincing.
Tottenham vs Paco Ferreira
There are two ways of looking at this one. From one perspective, a second defeat to Paco Ferreira would be hugely embarrassing. But on the other hand, getting rid of Europa Conference League obligations would allow Nuno Espirito Santo to fully concentrate on domestic matters.
A lot will depend on the team Spurs field in this second leg. Should the London outfit opt for a strong side, it may be worth backing them to progress.
However, with a Premier League game on Sunday against in-form Watford, Santo may give another chance to some of his fringe players.
Either way, both of these sides have not exactly excelled in the goalscoring department since the season got underway. With that in mind, under 2.5 goals is the way to go.