Jamie Vardy holds a record of nine goals from 15 appearances against Manchester City across all competitions. In fact, the 34-year-old has only scored more goals against one other club - Arsenal.
In their last outing, the Foxes beat the red side of Manchester 3-1 to progress into the FA Cup semi-finals for the first time since 1982.
Man City also progressed to the semi-finals after beating Everton 2-0; making it 21 wins from 22 games in the process.
Tip of the Fixture
Given Leicester's impressive performance against City earlier in the season, Guardiola's men should expect another difficult test. At the time of writing, bet365 are offering a price of 16/5 on a draw and in our eyes, that's the way to go.
Despite being close in the table, these two sides have not drawn with each other in their last 10 meetings (Man City have won 8, lost 2).
Having beaten Man City earlier this season, the Foxes will look to complete the league double over the table toppers for the first time since the 1986/87 Division One season.
In the 5-2 victory earlier this season, prolific striker Vardy bagged himself a hat-trick - the second time in his career he has done so against Man City.
Here, we take a look at the four games in which the Vardy has scored against Pep Guardiola's men:
Leicester City 4-2 Man City (King Power Stadium, December 10, 2016)
Last time these two sides met, Jamie Vardy stole the show having scored his first ever hat-trick in a Leicester City shirt.
It took the Englishman just three minutes to get his name on the scoresheet as he struck the ball first time past a helpless Claudio Bravo to gift his side an unprecedented lead.
After Andy King doubled Leicester's lead, Vardy then made it 3-0 by sliding past Bravo and slotting the ball into an open net.
Man City did claim two late consolation goals but it didn't take the spotlight away from Vardy who grabbed himself the match ball and a perfect 10.0 rating on whoscored.com.
Man City 5-1 Leicester City (Etihad Stadium, February 10, 2018)
Unfortunately for Leicester, a superb Vardy goal was not enough to stop the brilliance of Sergio Aguero on this occasion. The Argentine forward put four past Kasper Schmeichel as City ran riot at the Etihad.
With the score 1-0, Vardy intercepted the ball from Ilkay Gundogan and charged straight for defender Aymeric Laporte. The striker then excellently opened his body up just outside the box and hammered the ball into the bottom left corner to bring the scores level.
Whilst this turned out to be Leicester's only real chance from the one-sided game, it showed Vardy's prolific nature in front of goal and how much of a vital role he plays in his side's attack.
Aguero, who has recently announced he will be leaving Man City in the summer, was on fire in this game and proved to be on a different level to anyone else on the pitch.
Man City 3-1 Leicester City (Etihad Stadium, December 21, 2019)
With Leicester second and Man City third, it was an important match-up last season to see which team could close the gap on high-flyers Liverpool.
Vardy opened the scoring after 22 minutes as he brilliantly finished off a breakaway move following a strong Man City attack.
The Cityzens eventually proved too strong for Leicester, with Kevin De Bruyne delivering an inspirational performance in midfield.
Man City 2-5 Leicester City (Etihad Stadium, September 27, 2020)
Former Foxes man Riyad Mahrez put City in front after just four minutes. Later in that half, Vardy's tricky feet in the box forced Kyle Walker into a rash challenge, giving Leicester the opportunity to equalise from the spot.
Five minutes later, the hat-trick was complete after once again getting brought down in the box by defender Eric Garcia and converting from the spot kick.
His side went on to score two more goals to complete a stunning victory. Once again, a man of the match performance from Vardy proved too much for the Man City defence.
With Guardiola's men being unplayable at times this year, Vardy will need to produce a similar performance to this one earlier in the season if his side are to stand any chance of winning three points at the weekend.