Spurs are back in Premier League operations this weekend, travelling to the London Stadium and their captain, Harry Kane, could increase his superb scoring record against David Moyes' high-flying men.
Kane and Tottenham Hotspur return to the English capital on Sunday after Europa League action in Austria, as they make the short journey across town to visit West Ham (kick-off 12:00), who have had a sensational 2021 so far.
At 27 years old, Kane has already had his fair share of joy in this London derby, helping him become one of the top flight's most feared marksmen.
The London stadium was where Jose Mourinho took charge of his first Tottenham game 16 months ago, as his skipper scored in a 2-3 win; one of many goalscoring displays from the striker against the Irons which we're focussing on.
Planet Sport takes a look at Harry Kane's best outings against West Ham.
Kane has faced the Hammers 16 times in his career so far for three different clubs (Tottenham, Norwich City and Millwall), but all of his 11 goals have come in a Spurs shirt.
Enjoying things in front of goal has translated to enjoying the result, having never lost an encounter with West Ham in which he's scored.
Overall, his win rate versus the Irons is 43.75% but that rises to 53.84% when playing for the Lilywhites specifically.
He bagged two in the thrilling 3-3 reverse fixture earlier this season, making it three successive games with a goal against his capital competitors.
Top five performances
Tottenham Hotspur 3-3 West Ham United
October 18, 2020
We start with that thrilling reverse fixture, where Kane scored twice and assisted once in a ferocious first-half showing.
It was a complete performance from the skipper, as he won six aerial duels, fired off the same amount of shots, managed one dribble and had an immaculate passing accuracy of 100%.
Kane was given a perfect 10/10 rating on whoscored.com to boot, nothing less than an incredible individual display.
Spurs' captain couldn't stop a comeback, though, as West Ham scored three in the final 10 minutes of the match to earn a miraculous point and dent Tottenham's early title hopes.
Tottenham Hotspur 4-1 West Ham United
November 22, 2015
Handed the no.10 jersey following a 21-goal breakout Premier League campaign, two more strikes at White Hart Lane in this meeting went a way to making it 25 goals across 2015/16.
Among a mixed first half of the season, Spurs were looking to Kane to keep them in the title race as Leicester City famously took top spot that term.
Bagging another brace from another six shots - more than anyone else on the pitch - he quashed the 'one season wonder' claims, after a tough start to the campaign.
His two precise finishes, the second a trademark drive, made it five successive appearances with a goal (eight in total) in a club-record run of 12 Premier League games unbeaten.
Going on to finish third that season, something was building at Spurs and their then 22-year-old talisman was at the epicentre.
West Ham United 2-3 Tottenham Hotspur
September 23, 2017
To kickstart a four game top-flight winning run for his team, Kane struck twice again but this time in Stratford, to contribute to a personal best 30 league goals that campaign.
The current England captain beat former Three Lions goalkeeper and now club team-mate Joe Hart twice with two simple finishes before the break, in a 9/10 WhoScored-rated display.
A pair of completed dribbles and aerial duels bolstered his performance, in which the Hammers gave the Lilywhites a fright late on by scoring twice themselves in the second half.
Finishing third in the PL again - playing their home games at temporary venue, Wembley - and winning a Champions League group which included Real Madrid and Borussia Dortmund, Pochettino and his players, spearheaded by Kane, had established themselves as a force to be reckoned with.
Tottenham Hotspur 3-2 West Ham United
November 19, 2016
In the season between the past two we've covered, Tottenham and Kane went one worse and one better, with the striker racking up 29 league goals, while his team finished second.
Among the hallmarks of all successful sides are last-gasp wins, and Kane did exactly that in this one, scoring in the 89th and 91st minutes to sink West Ham in dramatic fashion.
It was breathless at the last White Hart Lane match between these London teams, with the Irons taking the lead twice before they were defeated at the death and finished with 10 men.
Statistically, his aforementioned performances were better, managing just three shots in a relatively quiet display, but the nerve to step up clutch was beyond his youthful years.
West Ham United 2-3 Tottenham Hotspur
November 23, 2019
We end with the last time Tottenham took a trip to the former Olympic Stadium, where the Mourinho era began.
The Special One was back managing and continued his perfect record of winning every first game when boss of an English side, thanks to Kane and co.
Racking up a stellar six aerial duels won, two tackles, one key pass and one goal, his prolific prowess helped Mourinho's tenure get off to a winning start.
The captain went onto score in the June home fixture and mustered an admirable 18 strikes during an injury-hit campaign.
Spurs only finished sixth, one place above where Moyes' men currently sit going into Sunday.
Tip of the Fixture
Kane is priced at 4/1 to score first or last in the weekend clash, while the striker is 7/5 to net at any time with Paddy Power.
An outlandish Kane to score first in a 2-3 Tottenham win, a common result in this fixture, is tipped at 130/1.
(Odds correct at time of writing, subject to change)