When: Friday, April 16, 2021
How to watch: Sky Sports Main Event
Everton are currently winless in four straight Premier League games and sit seven points behind fourth-placed West Ham.
Spurs, on the other hand, have only managed one win from four and trail the Hammers by six points.
Inconsistencies, lack of goals and a lack of results have hurt Everton and Tottenham's European ambitions however, the race is not over yet. In fact, this upcoming encounter could act as a springboard for a late top six - or even a top four - push.
Last Three Matches
Everton 5-4 Tottenham (FA Cup - February 10, 2021)
Last time these two clubs went head-to-head, viewers were treated to an absolute classic as Everton claimed an extra-time victory over Tottenham in the FA Cup.
Spurs took the lead after just three minutes courtesy of Davinson Sanchez. Mourinho's side held on to that one-goal lead for over 30 minutes before a total collapse would soon see them trail by two.
Everton scored three goals in seven minutes as a stunned Spurs team watched on in horror. Dominic Calvert-Lewin, Richarlison and Gylfi Sigurdsson scored the goals as the Toffees took control.
Spurs eventually stopped the rot and managed to half the deficit just before the break courtesy of Erik Lamela.
Sanchez scored his second in the second half to level the tie while further goals from Richarlison and Harry Kane saw the game enter extra-time.
Brazilian striker Bernard became Everton's match winner when his 97th minute goal sealed the win for the Toffees.
Tottenham 0-1 Everton (Premier League - September 13, 2020)
Unlike their FA Cup clash, television viewers were only treated to one goal on this occasion. Fortunately for the Toffees, it was Calvert-Lewin who scored it as Everton took all three points at the Tottenham Hotspur stadium.
This game took place during the opening weekend of the season and the result certainly gave Everton fans a lot of promise ahead of the new campaign.
Tottenham enjoyed more possession and created far more dangerous attacks however, in the end, Mourinho's men were left empty handed.
Tottenham 1-0 Everton (Premier league - July 6, 2020)
When these two clubs met in the previous campaign, it was a similarly cagey affair to the one we got in September.
On this occasion, Spurs enjoyed more possession and more dangerous attacks but crucially, they also outscored their opponents.
A Michael Keane own goal in the first half proved to be the difference maker as Spurs continued their charge for a top six finish.
Last ten head-to-head games
Everton wins: 2
Tottenham wins: 5
Everton goals: 14
Tottenham goals: 25
Two great managers collide
Carlo Ancelotti and Jose Mourinho. Two managerial behemoths.
Interestingly, the two men are part of a short list of five managers who have won the Champions League with two different clubs. Ancelotti achieved this with AC Milan and Real Madrid while Mourinho claimed the European honour with FC Porto and Inter Milan.
But times have certainly changed. Both managers are currently miles off qualifying for a European tournament - nevermind winning one.
However, that could change this Friday night. A win for either side would act as a huge practical and psychological boost in their European ambitions. Question is, which one of these two managerial greats will seize the moment?
European contenders in relegation form
Even though both clubs are battling for a place in Europe, they both are in the midst of a real slump.
Everton, for instance, have failed to win any of their last five games. Three defeats were followed by two draws but what's worse, is the fact that Ancelotti's men have only scored two goals during this entire run.
Tottenham, on the other hand, are not fairing any better. Mourinho's men have managed one win from their last five games - a run that has really dented their top four ambitions.
The problem for the Londoners however, is more to do with their defence. Spurs have conceded ten goals from their last five games - two of those against Newcastle.
With Everton failing to find a breakthrough against Brighton and generally struggling for goals, it's hard to nominate any Toffees player for a goals bet this Friday night.
Instead, Harry Kane could be a play here at 11/4 to score first. The Spurs forward is the Premier League's joint-top scorer with 19 to his name and he'll be keen to improve that tally.