A 1-0 defeat to Fulham at Anfield made it six home losses in a row for the Reds - the first time this has happened in the club's 129-year history.
Jurgen Klopp's men now sit eighth in the league table, and Champions League football next season appears to be a steep mountain to climb.
Wolves are also struggling for form having failed to win any of their last three games. Last weekend they drew 0-0 against Aston Villa.
Tip for the fixture
With both teams struggling to find wins lately, Skybet are offering odds of 13/5 for this match to end a draw.
Liverpool have won their last eight league matches against Wolves and have not lost away to them in the league since 1981.
Wolves have also scored just one goal against Liverpool in their last six meetings - the goal came in a 2-1 defeat at the Molineux last season.
Salah has featured in five games for Liverpool against Wolves, scoring just two goals in that time.
Here, we take a look at three games in which Salah left Wolves with nightmares.
Wolves 0-2 Liverpool - Molineux Stadium, December 21, 2018
A Man of the Match performance from the Egyptian helped Liverpool to a comfortable win over newly-promoted Wolves in 2018.
Salah opened the scoring, turning in a low ball from Fabinho past goalkeeper Rui Patricio.
Salah was influencial in every aspect of Liverpool's attack. He was awarded 'star player' with a rating of 8.7 on WhoScored.com.
Wolves 1-2 Liverpool - Molineux Stadium, January 23, 2020
The match was full of end-to-end action, with Bobby Firmino winning it for the Reds in the 84th minute following a piercing pass from Jordan Henderson.
Salah was unusually lacklustre with his shooting in this game however, he was responsible for nearly half of Liverpool's attempts at goal (six), and completed the most dribbles (five).
Liverpool 4-0 Wolves - Anfield, December 6, 2020
Once again it was the Egyptian who opened the scoring as he capitalised on a mistake by Conor Coady to gain possession and slip the ball past Patricio.
Georginio Wijnaldum got the second before Joel Matip headed in a delicious delivery from Salah to get Liverpool's third.
An own goal from Nelson Semedo made it four as the Reds crusied to victory.