From London to Milan, huge rivalries are set to be resumed across most of the major European leagues. Welcome to this special derby edition of Weekend Watch.
Southampton v Chelsea (Premier League) - Saturday 12:30 GMT
No, this is not one of the derby games on offer, but don't scroll down just yet. This fixture has the potential to be a very exciting contest - and a very important one for both clubs as well.
Southampton have lost six straight Premier League games and they're taking on a side which has beaten them in all five previous meetings at St Mary's.
Chelsea, on the other hand, have won four straight league games and are beginning to make a real claim for the top four.
Thomas Tuchel's men should get the job done with goals to spare.
Betting: Chelsea to win with a -1 handicap at 2/1 (PaddyPower)
Eintracht Frankfurt v Bayern Munich (Bundesliga) - Saturday 14:30 GMT
On paper this fixture may not be considered a 'derby' but it will certainly feel like one when the game kicks off.
Eintracht have enjoyed a tremendous campaign and they're coming into this game placed third in the table - ten points behind league leaders Bayern Munich.
Both teams are in good form and Eintracht, who are yet to lose a game at home, will fancy their chances against a Bayern side which is facing a growing injury list.
Betting: Double Chance - Eintracht Frankfurt and Draw at EVS (PaddyPower)
Liverpool v Everton (Premier League) - Saturday 17:30 GMT
This weekend's derby frenzy kicks off with a battle between two Merseyside clubs who are out of form and dropping down the Premier League standings.
Everton's Champions League ambitions have been dealt a huge blow courtesy of their recent form - one league win from six.
Liverpool will look to feed on Carlo Ancelotti's misery as they aim to back up their midweek win over RB Leipzig with victory in this, the 236th Merseyside derby.
This will be a good one!
Betting: Liverpool to win and both teams to score at 9/5 (PaddyPower)
Schalke 04 v Borussia Dortmund (Bundesliga) - Saturday 17:30 GMT
To the frustration of many soccer fans, the infamous Revierderby between Schalke and Borussia Dortmund will kick off at the same time as Liverpool v Everton.
Similarly to the Merseyside affair, this game also features two sides who are struggling for league form.
Schalke are destined for relegation while BVB risk missing out on those all-important Champions League places. These facts only add more fuel to the already burning inferno which is the heated rivalry between the two clubs.
This fixture rarely disappoints so expect goals - unfortunately for Schalke, expect the goals to be heading in one direction.
Betting: Borussia Dortmund to win and over 3.5 goals at 6/4 (PaddyPower)
Real Valladolid v Real Madrid (La Liga) - Saturday 20:00 GMT
Three straight league wins. Six goals scored. Only one conceded. Real Madrid seem to have recovered from their shock loss to Levante three weeks ago and they are closing the gap to league leaders Atletico Madrid.
Nonetheless, if Zinedine Zidane's men want to think about a serious title push, this fixture with Valladolid is a must-win game.
Pucelanos - who are owned by Madrid legend Ronaldo - are struggling for form and currently sit third from bottom. There's nothing to suggest they could put together a winning performance and a big win for the visitors is expected.
Betting: Real Madrid to win by two goals at 7/2 (PaddyPower)
West Ham v Tottenham (Premier League) - Sunday 12:00 GMT
You can't have a derby frenzy without a big game in London - so here it is.
West Ham have exceeded expectations this season and their game with Tottenham is a much anticipated one.
David Moyes has done what Jose Mourinho wanted to do but on a much tighter budget. The campaign is far from over and much can still change. However, there's no denying the Scot has done a terrific job with the Hammers.
This is shaping up to be a good derby which is too close to call.
Betting: Draw at 9/4 (PaddyPower)
Barcelona v Cadiz (La Liga) - Sunday 13:00 GMT
After a 4-1 trashing at the hands of PSG, Ronald Koeman's Barca return to league action this weekend.
The Catalan giants may not be the force of old. However, opponents Cadiz come into this game on the back of four straight La Liga defeats and Barcelona shouldn't have a problem taking all three points.
Betting: Barcelona to win with a -2 handicap at 11/8 (PaddyPower)
AC Milan v Inter Milan (Serie A) - Sunday 14:00 GMT
Are we about to experience one of the greatest Milan derbies of all time? It's certainly shaping up that way.
Two of Serie A's top teams, two of the main title contenders, two of the biggest rivals in world soccer and they're going head to head just a few weeks after a fiery encounter in the Coppa Italia - the ingredients are there for an absolute classic.
Who wins? That's a tough question. Perhaps a bet in the goal market is the safest way to go.
Betting: Over 2.5 goals at 13/20 (PaddyPower)
Arsenal v Manchester City (Premier League) - Sunday 16:30 GMT
Like all good masters, Guardiola doesn't seem to have passed on ALL of his knowledge to Arteta when the two worked together at the Etihad.
City are flying and are sitting top of the Premier League table. The same cannot be said about the Gunners who are currently tenth and face an uphill battle if they are to qualify for European soccer next season.
Arsenal looked good against Leeds last weekend but the Cityzens should take all three points.
Betting: Man City to win and both teams to score at 21/10 (PaddyPower)
Manchester United v Newcastle United (Premier League) - Sunday 19:00 GMT
Manchester United had fun this midweek as they demolished Real Sociedad 4-0 in the Europa League. Despite this, their defensive vulnerabilities were still clearly on show.
That isn't likely to be a problem though, as they're taking on a Newcastle United side which has only managed 25 goals all season.
The Magpies haven't won at Old Trafford in eight years and it looks like that run will continue for the foreseeable future.
Betting: Manchester United to win 2-0 at 11/2 (PaddyPower)
PSG v Monaco (Ligue 1) - Sunday 20:00 GMT
While not officially a derby, the rivalry between PSG and Monaco has been growing over the past decade.
Monaco may have dropped off a little over the last three seasons, but they look a force again under Niko Kovac. The former Bayern Munich manager has turned the side into potential title contenders and PSG will have a job on their hands.
However, Mauricio Pochettino's men absolutely demolished Barcelona in midweek and will have confidence in abundance.
I can't think of a better way to end the weekend.
Betting: Kylian Mbappe to score first at 11/4 (PaddyPower)