When: Saturday, May 1, 17:30 GMT
How to watch: Sky Sports Main Event
While the gap does offer breathing room, the Blues can't afford to rest on the laurels.
Thomas Tuchel's men have got one eye on the Champions League however, making the top four and qualifying for next season's edition is just as important.
Fulham, on the other hand, are currently seven points away from safety with five games remaining.
Survival is still a possibility but Scott Parker's side need to start picking up points… fast.
Last Three Premier League Matches
Fulham 0-1 Chelsea (January 16, 2021)
When these two clubs met earlier in the season, viewers were treated to a close contest as Chelsea picked up a 1-0 victory.
The opening half was rather quiet until the 44th minute. It was at this point when Fulham's Antonee Robinson received a straight red card for a serious foul.
Chelsea went on the attack in the second half but were often frustrated by an admirable effort in defence from the hosts.
Eventually, the Blues found their breakthrough courtesy of Mason Mount who grabbed the winner in the 78th minute.
Fulham 1-2 Chelsea (March 3, 2019)
There was another close encounter between the two clubs when they met back in 2019.
Gonzalo Higuain opened the scoring for the Blues on the 20th minute mark however, the visitors were pegged back by a Callum Chambers equaliser seven minutes later.
Jorginho reinstated Chelsea's lead on the half-hour mark and it proved to be the goal that would seal all three points for the Blues.
Chelsea 2-0 Fulham (December 2, 2018)
Things were a lot more one sided when the two sides met back in 2018.
Pedro put Chelsea in front after just four minutes of action at Stamford Bridge.
The Blues dominated possession and enjoyed more shots on target as Fulham struggled to get a foothold in the contest.
Ruben Loftus-Cheek settled the encounter by scoring Chelsea's second in the 82nd minute.
Last ten Premier League head-to-heads
Chelsea wins: 6
Fulham wins: 0
Chelsea goals: 15
Fulham goals: 4
Season defining month for Chelsea
One look at Chelsea's remaining fixtures underlines the importance of winning this weekend against Fulham.
The Blues will take on Man City, Arsenal, Leicester City and Aston Villa in their remaining four games. What's more, Tuchel's men also face a Champions League semi-final clash with Real Madrid and an FA Cup final showdown with the aforementioned Foxes.
On one hand, Chelsea could rise to the occasion and potentially seal a double winning season and a top four finish.
On the other, it could all go up in smoke and the Blues could be left with nothing. The pressure is certainly on.
Fulham Championship bound?
Is there any fight left in Fulham? Recent results would suggest the answer is no.
The Lilywhites ended their run of four straight defeats with a 1-1 draw away against Aston Villa.
However, one point from five games is not the sort of form that will keep Fulham away from relegation.
After their clash with Chelsea, Parker's men take on Burnley, Southampton, Man United and Newcastle.
Relegation can still be avoided but Fulham will need to win at least three of those games to give themselves a fighting chance.
In order to find a Chelsea player on the Premier League's top scorer charts, you need to scroll all the way down to number 40… Yes, FORTY!
There you will find Timo Werner. The German has scored a measly six goals this season.
To say the player has been a bit of a disappointment would be an understatement. With that in mind, our recommendation is to back Mason Mount to get amongst the goals at the current price of 3/1.