The Cherries and Swans are battling for the play-off places against one another, so three points are crucial for both in midweek.
Bournemouth go into Tuesday's game bruised by a 3-2 defeat to Barnsley in a hectic match on Saturday, which saw the South Yorkshire side open up a five-point gap to Jonathan Woodgate's men outside the top six.
It's vital, then, for the Cherries to take all three points against third-placed Swansea, who could jump into the automatic promotion places if they better Brentford's result on Tuesday.
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Brentford win - Derby County vs Brentford (7pm kick-off GMT): Brentford have been in steady form as they keep up their promotion push, keeping themselves ticking over - albeit falling slightly behind Watford and Swansea in recent weeks. Derby's early resurgence under Wayne Rooney has fallen away recently, however, with the Rams without a win in five going into this one. Brentford need the points to keep pace with the automatic promotion contenders, and they should get over the line on Tuesday night.
Middlesbrough win - Middlesbrough vs Preston North End (7pm kick-off GMT): A dominant 3-0 win against Stoke City at the weekend saw Boro maintain their slight hopes of climbing into the play-offs, while Preston have been in and out of form of late. They've travelled well this season, though, gaining eight of their 13 wins this season away from home. With Boro's home record being strong too, this will be a tight match - but we predict Middlesbrough will edge it.
Swansea City win - AFC Bournemouth vs Swansea City (7.45pm kick-off GMT): This is a tough one to call. As previously mentioned, it's the biggest game of the night with both teams in desperate need of a win. The Swans have had the better recent form of the teams and Andre Ayew has been red-hot in front of goal with five goals in his last five matches, so he could prove to be the difference on the night.