When: Thursday, May 6, 20:00 GMT
How to watch: BT Sport
Following a thrilling victory over Newcastle, the champions return to action with a game against Brighton.
This certainly has the makings of a great game with both teams presenting an entertaining style of football this season.
What's more, both teams could do with a victory as Man City look to build momentum ahead of their Champions League final and Brighton try to avoid the 'best of the rest' title.
Last Three Matches
Man City 1-0 Brighton (Premier League - January 13, 2021)
Man City took all three points and kept a clean sheet when they last met Brighton at the Etihad stadium.
Pep Guardiola's men dominated proceedings with 65% possession, 16 goal attempts, 726 passes and a total of 155 attacks.
Yet despite all that, it was Phil Foden's sole first-half goal which sealed the victory for the Cityzens.
Brighton 0-5 Man City (Premier League - July 11, 2020)
Guardiola's men were a lot more clinical when they visited the Amex back in 2020.
In the second-half, Bernardo Silva got his name on the scoresheet and Sterling bagged two more goals to complete a hat-trick.
Man City 4-0 Brighton (Premier League - August 31, 2019)
City put on another clinic when they hosted Brighton in the summer of 2019.
Kevin de Bruyne opened the scoring after two minutes as Sergio Aguero doubled their lead just before the break.
Aguero scored again shortly after the restart as City went into cruise control. Bernardo Silva added a fourth to make sure of the victory.
Last nine head-to-heads
Brighton wins: 1
Man City wins: 8
Brighton goals: 5
Man City goals: 24
All about momentum for Man City
The biggest game in Manchester City's history is just around the corner and Pep Guardiola's side will be looking to build momentum.
Victory in the Champions League final over Chelsea will finally cement City's ambition of becoming the number one club in Europe.
However, following their recent 2-1 loss to the Blues in the Premier League, the Cityzens could do with a couple of wins to restore confidence.
Their 4-3 victory over Newcastle put them back on the right track but can they continue to build momentum against Brighton this midweek?
Forget the table, Brighton are decent
They say the league table doesn't lie. But in this case, we disagree.
Brighton may be down in 17th but in reality, the Seagulls have played some brilliant attacking football this season.
The main issue for Graham Potter's men is the lack of a goalscorer. As things stand, Neal Maupay is the club's top scorer in the league with eight to his name.
Perhaps if the Seagulls can splash a few coins on a decent centre forward over the summer, they could challenge for a mid-table finish next season.
After scoring a hat-trick against Newcastle, Ferran Torres is likely to get another run-out here against Brighton.
The forward has scored all of his Premier League goals this season against teams in the bottom half of the table.
At 12/5 he's well priced to add to that tally.