When: Saturday, March 20, 20:00 GMT
How to watch: Sky Sports
Will Newcastle's lack of firepower cost them?
With Callum Wilson and Allan Saint-Maximin out injured and Miguel Almiron a doubt for the clash, Newcastle are lacking in the attacking department.
The Tynesiders, who have secured three consecutive draws, have only netted twice in those three stalemates - centre-back Jamal Lascelles being the scorer fixtures against Wolves and Aston Villa.
Newcastle's first-choice front three account for 16 out of the 28 goals scored by Steve Bruce's men this season. They are desperate for a reliable goalscorer and will struggle to pick up the points necessary unless there is a change in their fortune soon.
An over-reliance on Wilson, Saint-Maximin and Almiron could cost Newcastle dearly come the end of the season.
They are currently third-favourites to be relegated alongside the teams that currently occupy the bottom two spots in the table, Sheffield United and West Bromwich Albion.
Last three Premier League meetings:
Newcastle 0-3 Brighton (September 20, 2020)
Newcastle failed to have a shot on target as a below-par performance saw a dominant Brighton take all three points at St James' Park.
French striker Neal Maupay scored twice and set up the other of his team's goals, becoming the first player to do so in the Premier League for Brighton.
Two early goals inside the first 10 minutes set the Seagulls on their way to a comfortable victory.
Early in the second half, Newcastle had their best chance to score when Callum Wilson headed over from a superb cross by Miguel Almiron.
The game, however, was over as a contest on 83 minutes when Aaron Connolly curled in a shot after a decisive counter-attack.
Yves Bissouma was sent off late on for what seemed like an accidental kick to the face of Jamal Lewis, which was the only negative on an otherwise successful away trip for Brighton.
Brighton 0-0 Newcastle (July 20, 2020)
Hosts Brighton secured their Premier League safety, in an uneventful goalless draw at the Amex as they extended their unbeaten record in the Premier League against the Magpies.
The point moved Graham Potter's men seven points above the relegation zone with two games left to play, whereas Newcastle had already guaranteed their safety in previous weeks.
Maupay was unlucky not to be awarded a penalty for Brighton when Matt Ritchie brought him down. Newcastle's best opportunity fell to Andy Carroll who headed wide of the target late on.
Newcastle 0-0 Brighton (September 21, 2019)
Yet another 0-0 between the two sides, as Fabian Schar's overhead clearance was the highlight of the match. Steve Bruce's team had yet to experience victory at home under their locally born manager.
Both teams did have chances, Maupay was denied early on by Martin Dubravka and Joelinton headed wide for the home team.
Stephen Alzate had the ball in the net but an offside flag denied him after sustained Brighton possession. Then in the second half, Aaron Connolly thought he had scored, only for Schar to recover and acrobatically clear the ball on the line.
Brighton had one last chance to take all three points but Yves Bissouma's long-range effort was not powerful enough to worry Dubravka in the Newcastle net.
Head-to-head in the Premier League
Newcastle United won: 0
Brighton & Hove Albion won: 3
Newcastle United scored: 1
Brighton & Hove Albion scored: 6
Are Brighton finally turning chances into goals?
A 2-1 win against rivals Southampton moved Brighton three points clear of the relegation zone - ending a five-game winless run in the process.
Ironically, after dominating previous games and not coming out on top, they created fewer chances than their opponents but managed to take the chances that came their way.
Graham Potter's side have been performing well considering expected goals (xG) and expected goals against (xGA), however their below-par results leave them in 16th place and facing a relegation battle.
Brighton's hard-fought win against Ralph Hasenhuttl's outfit could perhaps be a turning point in their season, and they are starting to find an end product for their dominant displays.
Although the Seagulls find themselves in the lower reaches of the table, the bookies are confident that Brighton's performances will soon turn into points.
Score prediction: Brighton 1-0 Newcastle
This fixture usually sees a lack of goals and this meeting is likely to be no different. A win for both teams would do them the world of good and could change the complexion of the relegation battle completely, but the managers may well describe this match as 'must not lose' rather than 'win at all costs'.
Brighton showed grit and determination to win last week and changed formation at half-time following an injury to Dan Burn, highlighting the Seagulls' adaptability.
This is something Newcastle lack as they are seemingly one-dimensional in their play and offer little going forward, even on the counter-attack.
Brighton are almost certain to dominate possession and carve out chances for the likes of Neal Maupay, who is due a goal. Add to this their height in defence and they should have enough to suppress Newcastle's main threat, which is set pieces.
Even Brighton's poor home form should be irrelevant and Graham Potter and his men will be confident of securing a win against Newcastle.
Pascal Gross is Brighton's regular set-piece taker and in what could be a tight game, he might be the difference.