Wales legend Gareth Bale will reach his 100th cap for his country in Saturday's clash with Belarus.
It was Bale who was the matchwinner when these two sides met in Kazan earlier in the qualifying campaign, and Rob Page will be banking on him to be typically influential again.
A win would see Wales leapfrog the Czech Republic into second place in the group, so it's still all to play for.
When, where, and how to watch
When: Saturday, November 13, 19:45pm GMT
Where: Cardiff City Stadium
How to watch: Sky Sports
Best bets for Wales vs Belarus
When these two sides met earlier in the campaign it was something of a goalfest, and we could see a repeat of that given what's at stake.
Belarus have won just one of their seven matches in the group, so their hopes of qualifying evaporated some time ago.
However, they could easily be the care-free spoilers and that makes them dangerous, especially given what could be a nervy Wales team.
Of course, the build-up will be all about Gareth Bale, and he is a player who definitely thrives on responsibility in his national team.
When Wales need him he tends to step up, so expect a big performance here.
You can take advantage of a special Planet Sport Bet boost of 11/4 for Wales to win and Bale to score first.
Belarus 2-3 Wales (September 5, 2021)
When these two sides last met it was yet another great example of Gareth Bale dragging his country out of trouble and proving himself the difference-maker.
The Real Madrid man gave Wales an early lead from the penalty spot but two goals in a minute from Vitaly Lisakovich and Pavel Sedko on the half-hour completely turned the game on its head.
Bale levelled, again from the spot, midway through the second half before grabbing a dramatic winner deep into stoppage time.
Now or never for Wales and Bale?
There can be little doubt that the team of the last five years or so is the best that Wales have produced.
Led by Bale, they emerged from years in the soccer doldrums to make a huge impact at Euro 2016 and impress again at Euro 2020.
Between those two great European Championships, though, they failed to qualify for the World Cup in Russia.
In fact, they have failed to qualify for every World Cup since 1958. For this team, and Bale himself, this will be their last chance.
The likes of Ryan Giggs, Ian Rush and Mark Hughes never got to play in a World Cup finals, and Bale will be highly motivated to keep his own dreams alive in this one.
Goalscorer bets for Wales vs Belarus
Bale is obviously the name that stands out, and he can be backed to score the first goal at 12/5.
Belarus have scored just six goals in their seven games, and four of them came in one game against ten-man Estonia.
Vitaly Lisakovic is their top scorer in the competition and he has done it against Wales before, so take the Lokomotiv Moscow man at 12/1 if you fancy Belarus to grab the first goal of the contest.