On one hand, the Europa Conference League seems like an unwanted distraction for a side that really needs to focus on domestic duties.
Spurs haven't won a league game in September and have conceded 13 goals from their last five competitive games. In fact, Planet Sport currently have Santo as second favourite to be the next Premier League manager to leave his post.
On the other hand, this competition offers the team an opportunity to put aside their league woes as they try to build a bit of momentum.
When, where and how to watch
When: Thursday, September 30, 8pm BST
Where: Tottenham Hotspur Stadium
How to watch: BT Sport
Santo faces a tough choice ahead of Thursday's game. Does he field his strongest team in the hope of winning big and restoring confidence, or does he rest players ahead of a tough weekend clash against Aston Villa?
Clearly the game with Villa holds more importance but then again, a poor result against Mura would significantly ramp up pressure on the Portuguese manager.
We've already seen a number of shocks in Europe this week with the likes of Sheriff Tiraspol beating Real Madrid and Club Brugge winning away in Leipzig.
Only a comprehensive win will do for Tottenham. Luckily for the hosts, Mura are also out of form having won just one of their last four games.
Spurs don't offer much value in the betting but one offer which stands out comes in the match winning margin.
Three head-to-heads vs Slovenian opposition
Tottenham wins: 2
Slovenian opposition: 0
Tottenham goals: 6
Slovenian opposition: 3
Tottenham strong at home in Europe
Spurs might be seriously out of form but they'll take encouragement from the fact they're playing at home.
Tottenham have won all of their last seven home European games, scoring 25 goals and conceding just two.
With the home team targeting a turnaround and Mura managing just two away wins from eight, the hosts are unsurprisingly priced at 1/14 in the outright market.
However, if you're considering a bet builder, one interesting option is to back Tottenham in the half-time full-time market.
Nothing to lose
Mura might be major underdogs in this one but it must be said that stranger things have happened.
This is arguably the perfect time to play Tottenham and Mura - who arrive in London with no expectations - will essentially see this as a bit of a free hit.
For the Slovenian team, this will be their first test against an English side. Special occasions like these often bring out the best in players, no matter what form they're in.
Nevertheless, even a struggling Tottenham outfit shouldn't concede goals against a side of this calibre. With that in mind, Spurs to win to nil is our third recommendation.
Our pick is to go with Lucas Moura instead at around the 21/20 mark.
The 29-year-old Brazilian retuned from his injury last weekend but failed to impress in the 3-1 defeat against Arsenal.
However, Thursday's clash against the Slovenian minnows represents a good opportunity for the player to get back on track.