Before their injury crisis, Spurs won all three of their opening Premier League games and even flirted with the top spot. However, since half of their team have been left on the sidelines, the results have suffered.
When, where and how to watch
When: Sunday, September 19, 4:30pm BST
Where: Tottenham Hotspur Stadium
How to watch: Sky Sports
Follow this game live via our score centre
Before the Tottenham Hotspur stadium can be turned into a boxing arena for the Anthony Joshua fight, Spurs will be looking to land a blow of their own when they welcome Chelsea.
Nuno Espirito Santo's men haven't beaten the Blues in the league since late 2018 and a victory would certainly be the manager's biggest achievement since taking the job.
Spurs have major injury concerns with the likes of Heung-Min Son, Steven Bergwijn, Eric Dier, Lucas and Ryan Sessegnon all doubts ahead of the weekend.
If that wasn't enough to worry about, Giovani Lo Celso, Cristian Romero and Davinson Sanchez are still quarantining in Croatia following the international break.
Chelsea, meanwhile, only have one absentee as Christian Pulisic continues his recovery from his ankle injury.
On paper, Thomas Tuchel's side are expected to totally dominate proceedings. However, that was also the case against Zenit St Petersburg in the Champions League - a game which turned into a tougher test than first anticipated.
Despite this, the Blues are the ones to back. Chelsea don't offer much value in the outright market but at around the 13/8 mark, they are our pick to win to nil.
Last three meetings
Tottenham 0-1 Chelsea (Premier League - February 4, 2021)
Jorginho's converted penalty in the 24th minute proved to be the match winner as Chelsea took all three points last time these two teams met.
The scoreline proved rather disappointing considering there were 25 attempts on goal.
Chelsea 0-0 Tottenham (Premier League - November 29, 2020)
Last time these two sides clashed at the Bridge, both teams had to settle for a point.
On this occasion there were 18 goal attempts - all of them failing to find the back of the net.
Tottenham 1-1 (5-4 pens) Chelsea (EFL Cup - September 29, 2020)
Tottenham's last win over the Blues came in the Carabao Cup.
The two teams met in the Last 16 stage which saw Timo Werner and Erik Lamela bag goals in the regulatory 90 minutes.
The match proceeded to penalties which were won by the hosts. Chelsea's Mason Mount was the lone shoot-out casualty as his miss put Spurs into the quarter-final.
Last 10 head-to-heads
Tottenham wins: 4
Chelsea wins: 5
Tottenham goals: 10
Chelsea goals: 12
Is Chelsea's defence impenetrable?
The short answer is no. Liverpool and Villarreal can attest to that. The long answer though, is that Chelsea have arguably one of the strongest defences in the Premier League.
The Blues have only conceded two goals from six competitive games. What's more, they've bagged 11 goals themselves during that same period of time.
Tottenham - who are missing a large portion of their squad - failed to score past Crystal Palace last weekend. With that in mind, it's hard to see how they could get on the scoresheet against Europe's in-form team, Chelsea.
Yellow cards are never far in derby games. The same is true about this fixture which has seen 11 bookings last season.
Tottenham are likely to be doing most of the chasing in this one considering their injury crisis. With that in mind, Spurs to receive the most bookings is our tip at 20/21.
Thomas Tuchel's men have only conceded five bookings across that same number of games meaning they don't offer much hope in this market.
Romelu Lukaku is the man to watch when it comes to goals.
The Belgium international has already bagged three Premier League goals this season and is sure to be in the chase for the golden boot.
The player offers decent value in the anytime goalscorer market at around the 11/10 mark. However, our recommendation is for the forward to bag a brace at 9/2.