The Three Lions will be looking to maintain their perfect record of five wins from five games - a record that also includes 17 goals scored and just one conceded.
That one conceded goal came against Poland in their previous encounter. On that occasion it was England who prevailed 2-1 at Wembley but the Poles certainly gave Gareth Southgate's men a good run for their money.
Another close contest is expected on Wednesday as Poland look to reignite their hopes of automatic qualification. For England, it's an opportunity to further solidify their place as group leaders.
When, where and how to watch
When: Wednesday, September 8, 7:45pm BST
Where: PGE Narodowy, Warsaw
How to watch: ITV
Realistically speaking, a win over Poland would put England on the home stretch to automatic World Cup qualification.
Three more points in Warsaw would take England's total to 18, potentially opening up an eight-point gap at the top - though with Albania expected to beat San Marino that would more likely be six.
The remaining four games for the Three Lions are against Andorra, Hungary, Albania and San Marino; all matches which Southgate's men are expected to win comfortably.
However, picking up all three points in Poland is certainly a lot easier said than done. England have only won two of their last seven visits to the Eastern European nation and another tough test lies ahead.
The Poles have enjoyed a relatively successful international break following their 4-1 win over Albania and a 7-1 thrashing of San Marino.
Paulo Sousa's men became only the third nation in three years to concede a goal against San Marino and from a defensive perspective, the Poles have a lot of work to do.
However, with an attack consisting of Robert Lewandowski and MLS star Adam Buksa, England will need to keep their guard up.
With that in mind, we're backing England to win 2-1 in the correct score market - a bet which has landed in three of the last five head-to-head encounters.
Last three meetings
England 2-1 Poland (World Cup Qualifier - March 31, 2021)
England maintained their perfect qualifying record thanks to an 85th-minute winner at Wembley.
Harry Kane converted an early penalty to put the Three Lions ahead before Jakub Moder levelled things up in the second half.
The match was finely poised at 1-1 until Harry Maguire came to England's rescue with a winning goal five minutes from time.
England 2-0 Poland (World Cup Qualifier - October 15, 2013)
The Three Lions dominated proceedings at Wembley and prevailed in what was a must-win game.
Poland 1-1 England (World Cup Qualifier - October 17, 2012)
Poland's national stadium is one of few around the continent to have a retractable roof. Despite this, when forecasts warned about heavy rain in October 2012, the officials at the ground decided against its closure.
The downpour had a profound effect on the playing surface and caused the game to be postponed until the next day.
In the rearranged game, Rooney opened the scoring but Poland were able to rescue a draw thanks to a late Kamil Glik goal.
Last ten head-to-heads
Poland wins: 0
England wins: 8
Poland goals: 6
England goals: 19
Can England keep out goal-hungry Poles?
England's defence has been on point in recent times. In their 14 games in 2021, Gareth Southgate's men have only conceded three goals - not counting the penalty shootout against Italy.
Poland were one of the teams who managed to penetrate that almost water-tight defence and they will be confident of doing the same again on Wednesday night.
Robert Lewandowski is one the world's most in-form strikers. However, none of his 72 international goals have come against the Three Lions.
Since the start of the season, the Bayern Munich forward has bagged seven goals in four games for his club.
What's more, he's already scored three goals for Poland during this international break.
Lewandowski missed Poland's last game with England and he is certainly the man to watch in Warsaw.
Three Lions have their own goal threat
Poland may have their talisman but let's not forget about England's attacking options.
The Three Lions have scored eight goals in their last two games with six different players getting on the scoresheet.
Wednesday's game is shaping up to be an entertaining encounter with Poland desperate to get the victory and England seemingly scoring goals for fun.
With that in mind, our tip is to back an England win and both teams to score.
The aforementioned Lewandowski might be the man to watch but at 2/1, he currently offers the shortest odds for an anytime Polish goalscorer.
Considering the Poles rely a lot on set pieces, it may be worth backing a different name in the goalscorer market.
MLS star Adam Buksa scored four goals in his first two games for the Polish national team. At 6ft 3in, he certainly provides a serious aerial threat.
We're backing the New England Revolution striker to score a header at 9/1.
From England's perspective, Harry Kane leads the way in the market at around the 21/20 mark.
However, our tip is to back Raheem Sterling to continue his red-hot form for England.