Mark Noble was the man who failed to convert his spot-kick as Man United claimed a 2-1 victory at the London Stadium.
The Red Devils will now be looking to record successive wins over the Hammers as they target a place in the Carabao Cup's round of 16.
When, where and how to watch
When: Wednesday, September 22, 7:45PM BST
Where: Old Trafford
How to watch: Sky Sports
Considering the amount of competition in the Premier League and the Champions League, it's fair to say that the Carabao Cup represents his best hope of bringing silverware to Old Trafford this season.
The Red Devils have a chance to progress into the round of 16 when they host West Ham. However, winning against the Hammers is a lot easier said than done - something that United will be well aware of following last weekend's clash.
David Moyes and his men have enjoyed a strong start to the season, picking up eight points from their first five Premier League games.
What's more, the London outfit have also impressed in Europe with a 2-0 win over Dinamo Zagreb last week.
Man United, meanwhile, have also enjoyed a strong start. However, there has also been a familiar stench of inconsistency with the Red Devils who fell to a shock 2-1 loss against Young Boys last Tuesday.
Looking at the betting, the outright market should be avoided in a close game such as this. Instead, our tip is to back the match winning margin of one goal at around the 6/4 mark.
Last three meetings
West Ham 1-2 Man United (Premier League - September 19, 2021)
West Ham came within a whisker of securing a point against Man United last weekend.
Mark Noble had a chance to level the game in stoppage time only to see his penalty saved by David de Gea.
Man United 1-0 West Ham (Premier League - March 14, 2021)
On their last visit to Old Trafford, the Hammers were able to put on another good showing despite falling to an agonising defeat.
An own goal from Craig Dawson sealed the win, and the three points, for the Red Devils.
Man United 0-0 (1-0 aet) West Ham (FA Cup - February 9, 2021)
United were forced to deal with another stern West Ham challenge when they welcomed the London outfit to Old Trafford in early 2021.
This was the last cup clash between the two teams and it went all the way to extra time as neither side could find a breakthrough in 90 minutes.
However, it was the hosts who ultimately prevailed as Scott McTominay bagged the winner in the 97th minute.
Last ten head-to-heads
Man United wins: 6
West Ham wins: 2
Man United goals: 15
West Ham goals: 9
Rest time for Ronaldo?
After starting three games in eight days, it's unlikely we're going to see the 36-year-old Cristiano Ronaldo take to the field again. Or is it?
The Portuguese international has a knack for pushing the limits and proving people wrong. What's more, the player is in red-hot form having scored six goals across his last four games for club and country.
Solskjaer's men have a big game against Aston Villa at the weekend but the Red Devils won't want to play down the Carabao Cup this season.
Should the team fail to claim one of the major titles, they'll certainly want something to fall back on. Winning this competition may not be the ultimate dream but it will certainly underline progress for the so far trophyless Solskjaer era.
Considering the added importance of this game, we're going with a Man United win and both teams to score.
Major boost for Hammers
From one world beater to another, Michail Antonio could come back into the fold for West Ham.
The current joint-Premier League top scorer missed last weekend's clash due to a suspension. His return will certainly be an added boost for Moyes' side.
The player most recently featured in West Ham's 2-0 win over Dinamo Zagreb in the Europa League. It didn't take the Jamaica international long to make an impact as he scored the opener after just 22 minutes.
The 31-year-old can certainly be a thorn in United's defence should Moyes decide to field the forward upon his return to the team.
Jesse Lingard scored against his former loan team last weekend and he's our pick to get on the scoresheet once again.
The England international came off the bench to bag the winner last Sunday. He could have a lot more time to do the same onWednesday.
At 2/1, he represents good value in the anytime goalscorer market.