Both these great Lancashire rivals head into the game on the back of a 3-2 Champions League win although they were achieved in very different circumstances.
When: Sunday, October 24, 4.30pm BST
Where: Old Trafford
Best bets for Man Utd vs Liverpool
United's thrilling midweek win temporarily eased the growing pressure on Ole Gunnar Solskjaer after the Mancunians had taken just a single point from their last three Premier League games.
But major doubts still bubble under the surface and the speculation on his future could again ramp up if they lose here.
There are no such problems for Liverpool.
They're flying and, stretching back to last season, the Reds are unbeaten in 21 games in all competitions.
Jurgen Klopp's men head into the weekend sat second in the Premier League after five wins, three draws and no defeats, boasting a goal difference of +16.
Last three meetings between Man Utd and Liverpool
Man Utd 2-4 Liverpool (May 13, 2021)
It looked grim for Liverpool after 10 minutes. Klopp had never won in six previous trips to Old Trafford and they found themselves 1-0 down after an early strike from Bruno Fernandes was deflected in.
But needing to win to boost their hopes of pinching a Champions League spot, the Reds fought back to complete a deserved 4-2 victory.
Diogo Jota levelled after 34 before Roberto Firmino struck a double either side of the break (45 & 49) to give Liverpool breathing space.
Marcus Rashford cut the deficit midway through the second 45 to set up a tense finish before Mo Salah secured three huge points for the visitors with a breakaway strike in the final minute.
Man Utd 3-2 Liverpool (January 24, 2021)
A week after they'd played out a 0-0 stalemate in the league at Anfield (see below), this FA Cup clash was a far more entertaining encounter.
Salah scored his first goal at Old Trafford to give Liverpool the lead inside 20 minutes before Mason Greenwood (26) and Rashford (48) swung the tie in United's favour.
Salah levelled just before the hour-mark with his second of the game but the hosts struck the decisive blow when second-half substitute Fernandes blasted home an excellent 78th-minute free-kick to send United through.
Both teams had 14 shots overall and six each on target.
Liverpool 0-0 Man Utd (January 17, 2021)
Before they went on a horror run of six straight home losses, Liverpool played out a drab 0-0 draw with United at Anfield.
Given what was to come, the visitors would see this as a missed opportunity and, indeed, Solksjaer used that phrase post-match after watching his side carve out the better opportunities.
Alisson made good saves from Fernandes and Paul Pogba while stuttering Liverpool carved out very little.
Last 10 meetings
Liverpool wins: 3
Man Utd wins: 2
Liverpool goals: 14
Man Utd goals: 10
Liverpool can pick off flaky hosts
Liverpool were far from perfect in their midweek 3-2 win against Atletico Madrid in the Wanda Metropolitano.
But let's just pause and re-read that last sentence. Forget the first half of it and instead focus on the fact that they went to one of the hardest away grounds in the game and scored three goals.
Nobody does that and, indeed, the post-match stats showed that Atletico had never previously conceded three times at home in the Champions League under Diego Simeone (manager there since 2011).
Amazingly, Liverpool have scored three or more goals in all seven of their away games this season, twice racking up five.
On that basis and with United shipping goals - they have just one clean sheet in their last 20 - let's back Liverpool to score Over 2.5 goals at 3/1.
With so many talented forward players, I think United will get on the scoresheet too.
But Liverpool hold the aces here. Klopp and his side smashed a psychological barrier by winning at Old Trafford at the end of last season and they can do so again.
However, rather than backing Liverpool at just 5/4 for the win, head to the Match result and both teams to score market and back the Reds at 13/5.
Goalscorer bets for Man Utd vs Liverpool
Salah is the first point of call and the Egyptian became the first Liverpool player to score in nine successive games when netting in Madrid on Tuesday.
He also scored three times at Old Trafford last season so the 11/10 for Salah in the anytime market is just fine.
But the one that appeals at a bigger price is Roberto Firmino.
The Brazilian bagged a hat-trick at Watford and scored twice in this fixture last season.
All six of his goals this season have been away from home so the 21/10 for him to net on the road again appeals.
Ronaldo is 6/5 to score anytime. He's scored six in eight appearances since returning to Man Utd so, on those numbers, the price is fair.
The dangerman for Liverpool could be Rashford.
The England striker has scored five times in five Old Trafford appearances against Liverpool and he's scored in both games since returning from injury last week.
However, keep an eye on team news after he limped off with a dead leg against Atalanta.
If fit, Rashford is definitely an anytime scorer option at 5/2.